Dec 1, 1984

Xanthine oxidase in rabbit plasma after application of a bovine milk preparation to small intestine

Archives internationales de physiologie et de biochimie
B Schoutsen, J W De Jong


The absorption of xanthine oxidase into the bloodstream was studied in rabbits given a milk/cream preparation, fortified with 130 U bovine milk xanthine oxidase or the milk/cream preparation alone (control). The preparations were injected trans-abdominally into the intestines. The rise of plasma xanthine oxidase/dehydrogenase activity was studied with a radioenzymatic assay with and without NAD+. In rabbits, which received the fortified mixture, the plasma xanthine oxidase increase in 8 h was six times more than the increase in control animals (P less than 0.001). In both groups plasma xanthine dehydrogenase activity increased 3-4 times (P less than 0.001), without a significant difference between the two groups. We estimate that only 0.003%, or about 3 micrograms, of the xanthine oxidase added, is absorbed as an active enzyme from the intestine.

  • References15
  • Citations1


  • References15
  • Citations1


Mentioned in this Paper

Small Intestinal Wall Tissue
Bos taurus
Xanthine Oxidase
Entire Small Intestine
Intestinal Wall Tissue
Neoplasm of Uncertain or Unknown Behavior of Small Intestine
Blood Circulation
XDH gene
Xanthine Dehydrogenase

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