Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction

Journal of Cardiovascular Electrophysiology
Masao SakabeHiroshi Inoue

Abstract

Oxidative stress could be a possible mechanism and a therapeutic target of atrial fibrillation (AF). Xanthine oxidase (XO) inhibition reduces oxidative stress, but the effects of XO inhibitor on AF have not been evaluated. Hence, we assessed the effects of XO inhibitor, allopurinol, on progression of atrial vulnerability in dogs associated with tachycardia-induced cardiomyopathy. The dogs were subjected to atrial tachypacing (ATP, 400 bpm) without atrioventricular block for 4 weeks. The dynamics of atrial-tachycardia remodeling were evaluated in allopurinol-treated dogs (ALO, n = 5), placebo-treated controls (CTL, n = 6), and sham-operated dogs (n = 6). In CTL dogs, 4 weeks of ATP significantly increased AF duration (DAF; from 0.2 ± 0.2 seconds to 173 ± 67 seconds, P < 0.05) and decreased atrial effective refractory period (ERP; from 152 ± 9 milliseconds to 80 ± 4 milliseconds at a cycle length of 350 milliseconds, P < 0.01). Allopurinol attenuated the ATP effects on ERP (118 ± 6 milliseconds, P < 0.01) or DAF (0.6 ± 0.3 seconds, P < 0.05). In CTL dogs, ATP-induced rapid ventricular responses decreased left ventricular ejection fraction (LVEF; from 58.6 ± 0.1 to 23.5 ± 2.4%, P < 0.01), and increased left atrial diameter (LAD; f...Continue Reading

References

Jul 10, 2002·Circulation·Colin A J FarquharsonAllan D Struthers
Nov 5, 2002·European Journal of Heart Failure·Maarten P van den BergDirk J van Veldhuisen
Aug 6, 2003·American Journal of Physiology. Cell Physiology·Yong Chool Boo, Hanjoong Jo
Dec 25, 2003·The Journal of Physiology·Cristine E Berry, Joshua M Hare
Nov 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kan SaitoRyozo Nagai
Feb 12, 2005·Antioxidants & Redox Signaling·Atsushi Matsuzawa, Hidenori Ichijo
Apr 21, 2005·Kidney International·Uday M KhoslaRichard J Johnson
Jun 21, 2005·Journal of Molecular and Cellular Cardiology·Luciano C AmadoJoshua M Hare
Nov 24, 2005·Journal of Cardiovascular Electrophysiology·Masao SakabeHiroshi Inoue
Dec 17, 2005·Circulation Research·Khalid M MinhasJoshua M Hare
Feb 3, 2007·Cardiovascular Research·Akiko Shiroshita-TakeshitaStanley Nattel
Jun 14, 2008·Journal of the American College of Cardiology·Joshua M HareUNKNOWN OPT-CHF Investigators

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Citations

Dec 3, 2014·The Canadian Journal of Cardiology·Ri-Bo TangChang-Sheng Ma
Dec 2, 2015·Biochimica Et Biophysica Acta·Sören BrandenburgStephan E Lehnart
Jul 15, 2015·Scientific Reports·Wenjun XieAndrew R Marks
Sep 6, 2015·International Journal of Cardiology·Audrey H WuGerasimos Filippatos
May 9, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi NumaHiroshi Inoue
Dec 17, 2014·Biochimica Et Biophysica Acta·Carmen WolkeUwe Lendeckel
Mar 19, 2015·Journal of Diabetes Research·Hany M El-BassossyAbdulrahman M Alahdal
Jul 12, 2016·International Heart Journal·Nani MaharaniIchiro Hisatome
May 12, 2016·Annals of the Rheumatic Diseases·Jasvinder A Singh, Shaohua Yu
Feb 6, 2017·Cardiovascular Research·Jan Dudek, Christoph Maack
Aug 31, 2018·International Heart Journal·Tomoharu YoshizawaJunya Ako
Jul 14, 2018·Free Radical Research·Panagiotis KorantzopoulosTong Liu
Sep 21, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Chang Hee KwonKi-Chul Sung
Jul 20, 2017·Current Medicinal Chemistry·Alexios S AntonopoulosDimitris Tousoulis
Jul 6, 2020·Clinical and Experimental Pharmacology & Physiology·Jiayong ZhangJin Guo
Sep 7, 2019·Nutrients·Thomas Senoner, Wolfgang Dichtl
Sep 10, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroshi Inoue
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Rossella D'OriaFrancesco Giorgino
Dec 8, 2020·Oxidative Medicine and Cellular Longevity·Kai WangLuyu Zhou
Jan 4, 2021·Journal of cardiology·Yuichi SaitoYoshio Kobayashi
Aug 6, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Xuehan WangYujiao Zhang

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