Xanthine oxidase inhibition prevents mesenteric blood flow deficits after resuscitated hemorrhagic shock by preserving endothelial function

The Journal of Surgical Research
W J FlynnE L Hoover

Abstract

To determine the contribution of xanthine oxidase-mediated endothelial dysfunction to the blood flow deficits seen in the mesenteric circulation after resuscitated hemorrhagic shock, rats were prepared for intravital microscopic study then bled to 50% of baseline blood pressure for 60 min. Treatment animals received a 50 mg/kg bolus and a 25 mg/kg/hr infusion of the xanthine oxidase inhibitor allopurinol (allo) after shock but before resuscitation with shed blood and an equal volume of Ringer's lactate. A similarly resuscitated group (Std Res) and a nonhemorrhage group served as controls. Endothelial function was quantified at baseline, 30 min (R30), and 90 min (R90) postresuscitation as a change in mesenteric vessel diameter after topical application of acetylcholine (Ach), an endothelial-dependent vasodilator. Resuscitation restored cardiac output and blood pressure in both groups. First-order arteriolar blood flow (A1) remained depressed in the Std Res group but was restored to baseline in the group treated with allo. A1 arterioles demonstrated a 22 and a 27% reduction in ability to dilate to Ach at R30 and R90 after Std Res. V1 venules demonstrated a 39 and a 36% reduction in ability to dilate to Ach at R30 and R90 after St...Continue Reading

References

Sep 8, 1978·Science·I Fridovich
Mar 3, 1992·European Journal of Pharmacology·M R SiegfriedA M Lefer
Jun 3, 1992·Journal of the National Cancer Institute·R G Kilbourn, O W Griffith
Aug 1, 1991·Cardiovascular Research·Z BenyóA G Kovách
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
May 1, 1990·Hypertension·S M GardinerS Moncada
May 1, 1984·Prostaglandins·G Feuerstein
Aug 1, 1982·The Journal of Surgical Research·T IsoyamaC H Shatney
Jan 1, 1993·Journal of Cardiovascular Pharmacology·G M Rubanyi
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Apr 1, 1995·American Journal of Respiratory Cell and Molecular Biology·M D SchwartzE Abraham
Oct 1, 1993·Free Radical Biology & Medicine·S TanD A Parks
Nov 1, 1993·Annals of Surgery·M G Davies, P O Hagen
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·A M Lefer, D J Lefer

❮ Previous
Next ❯

Citations

Jun 28, 2005·Annals of Vascular Surgery·John B Seal, Bruce L Gewertz
Dec 13, 2007·World Journal of Surgery·Anubhav MittalJohn A Windsor
Jul 17, 2018·Drug Metabolism Reviews·Aneesh A Argikar, Upendra A Argikar
Jun 2, 2007·Journal of Human Hypertension·T de A CoutinhoI J Kullo
Jan 25, 2005·Shock·Maha AbdelrahmanChristoph Thiemermann
Jul 21, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Anoek L I van LeeuwenCharissa E van den Brom
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Deborah M Lenda, Matthew A Boegehold
Nov 25, 2020·The Journal of Trauma and Acute Care Surgery·François KhazoomEmmanuel Charbonney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.