Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers

Journal of Ethnopharmacology
T UnnoT Kakuda

Abstract

Xanthine oxidase (XOD) is a key enzyme playing a role in hyperuricemia, catalyzing the oxidation of hypoxanthine to xanthine and then to uric acid. This study aimed to identify the XOD inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), which was traditionally used as a folk medicine in the Philippines. Using a bioassay-guided fractionation technique, two active compounds were isolated from the aqueous extracts of the Lagerstroemia speciosa leaves, namely valoneic acid dilactone (VAD) and ellagic acid (EA). The result demonstrated that the XOD-inhibitory effect of VAD was a stronger than that of allopurinol, a clinical drug used for XOD inhibitor, with a non-competitive mode for the enzyme with respect to xanthine as the substrate. These results may explain and support the dietary use of the aqueous extracts from Lagerstroemia speciosa leaves for the prevention and treatment of hyperuricemia.

References

Feb 15, 1996·The New England Journal of Medicine·B T Emmerson
Feb 1, 1996·Bioscience, Biotechnology, and Biochemistry·T KakudaM Kuroyanagi
Oct 12, 2000·Journal of Ethnopharmacology·L D KongR X Tan
Apr 12, 2001·Journal of Ethnopharmacology·A P SweeneyJ L Markham
Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hirokazu HosoyamaTakami Kakuda
Jun 17, 1961·Nature·D P CAREW, T F CHIN

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Citations

Mar 8, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yang LiuZhiqiang Liu
Aug 30, 2012·The American Journal of Chinese Medicine·Chien-Wei HouKee-Ching Jeng
Jan 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yeu-Ching ShiShe-Ching Wu
Sep 4, 2012·Journal of Ethnopharmacology·Oratai NeamsuvanKholeel Mosamae
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S Y WangS T Chang
Nov 23, 2013·Journal of Food Science·Makoto KondoTsuyoshi Watanabe
Dec 1, 2009·Biotechnology Journal·Ganapathy SivakumarJackson O Lay
Aug 25, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Vishal JainH N Shivaprasad
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Lan X Chen, H Ralph Schumacher
Jul 11, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Shang-Tse HoJyh-Horng Wu
Aug 23, 2012·Peptides·Alice B Nongonierma, Richard J Fitzgerald
Apr 23, 2011·Expert Opinion on Therapeutic Patents·Raj KumarRajveer Singh
Aug 4, 2012·Pharmaceutical Biology·Li-Tao YiCheng-Fu Li
May 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wylly Ramsés García-Niño, Cecilia Zazueta
May 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Li-Min LiuTzong-Der Way
May 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingqun HuangXiaoxing Zhu
Feb 25, 2014·Phytochemistry·Sheng-Fa Tsai, Shoei-Sheng Lee
Sep 3, 2014·European Journal of Pharmacology·Mohammad Taghi MansouriBehnam Ghorbanzadeh
Oct 9, 2014·Journal of Asian Natural Products Research·Yu-Shuai PengXiu-Wei Yang
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Shinichi HondaDai Hirata
May 18, 2017·Phytotherapy Research : PTR·Navneet KaurGeetika Sirhindi
Nov 8, 2018·Chemical Biology & Drug Design·Arshad MehmoodChengtao Wang
Oct 10, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Lan X Chen, H Ralph Schumacher
Aug 8, 2018·BMC Complementary and Alternative Medicine·Tasnuva SharminHabiba Mohammadi
Sep 18, 2009·Neurochemical Research·Víctor LópezMaria Isabel Calvo
Apr 10, 2018·Frontiers in Pharmacology·Fazleen I Abu BakarSusi Endrini
Aug 5, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Young-Sil LeeDong-Seon Kim
Oct 29, 2020·BMC Complementary Medicine and Therapies·Nor-Ashila AladdinJamia Azdina Jamal
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maël GainchePierre Chalard
Jun 20, 2021·International Journal of Biological Macromolecules·Yin WanMingyong Xie

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