Xanthine oxidase inhibitory activity of Lychnophora species from Brazil ("Arnica")

Journal of Ethnopharmacology
Z S Ferraz FilhaD A Saúde-Guimarães

Abstract

Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the enzyme that catalyses the metabolism of hypoxanthine and xanthine into uric acid. Sixteen extracts were tested. All of them were found to have excellent XO inhibitory activity, with inhibitions greater than 38% at 100 microg/mL in the assay mixture. The most active plants examined were Lychnophora trichocarpha, Lychnophora ericoides, Lychnophora staavioides and Lychnophoriopsis candelabrum, with inhibitions of 77%, 78%, 66% and 63% at 100 microg/mL, respectively, and IC(50) values of 6.16, 8.28, 33.97 and 37.70 microg/mL, respectively.

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Citations

Oct 22, 2013·BMC Complementary and Alternative Medicine·Viviane G C AbreuAntônio F C Alcântara
Sep 16, 2011·Pakistan Journal of Biological Sciences : PJBS·Mindiédiba Jean BangouOdile Germaine Nacoulma
Jul 23, 2014·BioMed Research International·Urszula Gawlik-DzikiJarosław Czyż
Dec 25, 2007·Journal of Ethnopharmacology·L S GuzzoA Grabe-Guimarães
Mar 24, 2007·Bioorganic & Medicinal Chemistry·Jung-Feng HsiehShui-Tein Chen
May 24, 2012·Phytotherapy Research : PTR·Fernanda C FerrariDênia A Saúde-Guimarães
Dec 17, 2014·Journal of Ethnopharmacology·Rita de Cássia Lemos LimaDênia Antunes Saúde-Guimarães
Mar 23, 2011·Journal of Ethnopharmacology·P Capelari-OliveiraD A Saúde-Guimarães
May 28, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hui-Peng SongPing Li
May 23, 2009·International Journal of Food Sciences and Nutrition·Jin-Hee KimKyung-Young Yoon
Dec 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olívia R PereiraSusana M Cardoso
Jun 30, 2019·Journal of Ethnopharmacology·Camila Martins de Sá MüllerDênia Antunes Saúde-Guimarães
Jul 30, 2021·Journal of Ethnopharmacology·Camila Helena BarrosDênia Antunes Saúde-Guimarães

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