PMID: 7333967Dec 1, 1981Paper

Xanthocillin X monomethyl ether, a potent inhibitor of prostaglandin biosynthesis

The Journal of Antibiotics
N Kitahara, A Endo

Abstract

Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of Dichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 microM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 microM. The inhibition of xanthocillin X monomethyl ether was reversible. Of the enzymatic steps involved in the synthesis of prostaglandins and thromboxanes tested, conversion of arachidonic acid into prostaglandin H2 was specifically inhibited by xanthocillin X monomethyl ether. Anti-inflammatory activity of this antibiotic on carrageenan-induced oedema in the rat foot was, however, not detectable.

Citations

Mar 15, 2015·Chemistry & Biodiversity·Bárbara S F RodriguesMaria C F Oliveira
Mar 28, 2020·Chemical Research in Toxicology·Ubaldina GalliSilvio Aprile
Jul 2, 2021·Chemical Reviews·Alberto MassarottiGian Cesare Tron

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