Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport

The Journal of Nutritional Biochemistry
Hiroshi HirataKatsunori Ikewaki

Abstract

Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important antiatherogenic property of HDL; therefore, we investigated the effects of xanthohumol on macrophage-to-feces RCT using a hamster model as a CETP-expressing species. In vivo RCT experiments showed that xanthohumol significantly increased fecal appearance of the tracer derived from intraperitoneally injected [3H]-cholesterol-labeled macrophages. Ex vivo experiments were then employed to investigate the detailed mechanism by which xanthohumol enhanced RCT. Cholesterol efflux capacity from macrophages was 1.5-fold higher in xanthohumol-fed hamsters compared with the control group. In addition, protein expression and lecithin-cholesterol acyltransferase activity in the HDL fraction were significantly higher in xanthohumol-fed hamsters compared with the control, suggesting that xanthohumol promoted HDL maturation. Hepatic transcript analysis revealed that xanthohumol increased mRNA expression of abcg8 and cyp7a1. In addition, protein expr...Continue Reading

Citations

Sep 27, 2019·Foods·Patricia Vázquez LoureiroLetricia Barbosa-Pereira
Jun 4, 2019·EBioMedicine·Leah Guthrie, Libusha Kelly
Jan 20, 2021·Phytotherapy Research : PTR·Saba SoltaniAmirhossein Sahebkar
Nov 13, 2019·Biochemical and Biophysical Research Communications·Ami Ota-KontaniMariko Harada-Shiba
Nov 9, 2020·Biochemical and Biophysical Research Communications·Takahiro YamazakiYasuhisa Ano
May 1, 2021·International Journal of Molecular Sciences·Vancha HarishAnupam Bishayee

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