Xanthoma of the sacrum

Skeletal Radiology
Guo-Shu HuangCheng-Yu Chen

Abstract

Xanthoma is a lesion containing abundant foamy histiocytes most commonly occurring in superficial soft tissues such as skin, subcutis, or tendon sheaths. The involvement of deep skeletal structures, however, is rare and has only been infrequently reported in the English literature. Most xanthomas occur in patients with hyperlipidemic disorders. We report a case of a xanthoma in the sacrum and ilium of a patient with hyperlipidemia type IIa, who had chronic lower back pain for more than 20 years. On radiographs the lesion appeared multiloculated and osteolytic with a thin sclerotic border and containing multiple nodular calcifications within its matrix. Computed tomographic images revealed a presacral soft-tissue mass that also infiltrated the adjacent sacroiliac joint and iliac fossa. On histologic examination, abundant areas of xanthoma cells and cholesterol clefts, typical of xanthoma, were present. The patient received simple curettage of the lesion, and his symptoms were markedly relieved.

References

Mar 1, 1976·The British Journal of Radiology·A KovacV Sagar
Oct 1, 1988·American Journal of Clinical Pathology·F BertoniF H Sim
Nov 1, 1986·Clinical Nuclear Medicine·J Y LeeA Torres
Mar 1, 1985·The British Journal of Radiology·I J FinkR E Gregg
Apr 1, 1973·The Journal of Pathology·K W WaltonD J Dunkerley
Feb 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A FerlitoS Bordin
Jan 16, 1981·JAMA : the Journal of the American Medical Association·M L TurnerM K Dalinka
Sep 1, 1995·Spine·D P RobertsonI E McCutcheon
Jan 8, 1999·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·P Kinberg
May 9, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael PitmanAugustine L Moscatello
May 29, 2003·Clinical Orthopaedics and Related Research·Dante DallariArmando Giunti

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Citations

Oct 2, 2008·Skeletal Radiology·Tomoaki TorigoeHisashi Kurosawa
Sep 7, 2012·Case Reports in Endocrinology·Hasnae GuerroujNouzha Benrais
Dec 7, 2011·Best Practice & Research. Clinical Rheumatology·Gérard ChalèsPascal Guggenbuhl
Aug 9, 2015·Head and Neck Pathology·Dominic MorelPatrick J Nolan
Dec 24, 2018·Ocular Oncology and Pathology·Frederick A JakobiecSuzanne K Freitag

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