PMID: 751645Dec 1, 1978Paper

Xanthommatin biosynthesis in wild-type and mutant strains of the Australian sheep blowfly Lucilia cuprina

Biochemical Genetics
K M Summers, A J Howells

Abstract

The synthesis of eye pigments has been studied in the seven eye color mutants of the Australian sheep blowfly, Lucilia cuprina. Six appears to be affected primarily in the synthesis of xanthommatin. In wild type, the onset of xanthommatin biosynthesis occurs midway through metamorphosis. Developmental patterns of accumulation of the xanthommatin precursors tryptophan, kynurenine, and 3-hydroxykynurenine have also been established for wild type. By determining the levels of these precursors in late pupae of the mutants, it has been shown that the mutant yellowish accumulates excess tryptophan and the mutant yellow accumulates excess kynurenine. The implications of these results--that yellowish lacks tryptophan oxygenase, thus failing to convert tryptophan to kynurenine, and that yellow lacks kynurenine hydroxylase (blockade in the conversion of kynurenine to 3-hydroxykynurenine)--have been confirmed. This has involved in vitro assays of tryphophan oxygenase and precursor feeding experiments. The precursor accumulation patterns are less clear for the other mutants.

References

Aug 26, 1975·Biochimica Et Biophysica Acta·G P Moore, D T Sullivan
Apr 1, 1975·Biochemical Genetics·A J Howells, R L Ryall
Jan 1, 1975·Analytical Biochemistry·A Dalby, C Y Tsai
Apr 1, 1952·Proceedings of the National Academy of Sciences of the United States of America·M M Green

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Citations

Jul 1, 1996·Insect Biochemistry and Molecular Biology·L D WhiteD A O'Brochta
Apr 15, 2006·Photochemistry and Photobiology·Jolon M DyerWarren G Bryson
Oct 31, 2006·Journal of Insect Physiology·Qian HanJianyong Li
Jul 6, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·J M DyerW G Bryson
Feb 1, 1997·Genome Génome / Conseil National De Recherches Canada·C M Challoner, R H Gooding
Feb 14, 2002·Insect Molecular Biology·J C HeinrichM J Scott

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