PMID: 19926935Nov 21, 2009Paper

Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells

Journal of Pharmacological Sciences
You-Jin KangSang Kook Lee

Abstract

Xanthorrhizol is a sesquiterpenoid from the rhizome of Curcuma xanthorrhiza. In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model. However, the exact mechanisms for its inhibitory effects against cancer cell growth have not yet been fully elucidated. In the present study, we investigated the growth inhibitory effect of xanthorrhizol on cancer cells. Xanthorrhizol dose-dependently exerted antiproliferative effects against HCT116 human colon cancer cells. Xanthorrhizol also arrested cell cycle progression in the G0/G1 and G2/M phase and induced the increase of sub-G1 peaks. Cell cycle arrest was highly correlated with the downregulation of cyclin A, cyclin B1, and cyclin D1; cyclin-dependent kinase 1 (CDK1), CDK2, and CDK4; proliferating cell nuclear antigen; and inductions of p21 and p27, cyclin-dependent kinase inhibitors. The apoptosis by xanthorrhizol was markedly evidenced by induction of DNA fragmentation, release of cytochrome c, activation of caspases, and cleavage of poly-(ADP-ribose) polymerase. In addition, xanthorrhizol increased the expression and promoter...Continue Reading

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Citations

Sep 6, 2014·Journal of Food Science and Technology·Rinaldi SaleaRaymond R Tjandrawinata
Apr 10, 2010·Bioscience, Biotechnology, and Biochemistry·Jin-Eun KimKwang-Kyun Park
Jul 23, 2013·Journal of Biochemical and Molecular Toxicology·Mauro C X PintoElaine M de Souza-Fagundes
Apr 3, 2012·Biochemical and Biophysical Research Communications·Thiam-Tsui TeeLope Pihie Azimahtol Hawariah
Jun 12, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rastislav JendželovskýPeter Fedoročko
Aug 2, 2012·Journal of Pharmacological Sciences·Wei HeJianping Chen
May 28, 2016·Critical Reviews in Food Science and Nutrition·Wen SunXiuping Chen
Oct 6, 2010·Natural Product Reports·Braulio M Fraga
May 6, 2015·Phytotherapy Research : PTR·Cheppail RamachandranSteven J Melnick
Oct 27, 2015·Cancer Cell International·Seok Fang OonYew Hoong Cheah
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Aug 12, 2017·Experimental and Molecular Pathology·Mzwandile MbeleZodwa Dlamini

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