XCdh1 is involved in progesterone-induced oocyte maturation

Developmental Biology
Catherine PapinElisabeth Mandart

Abstract

The molecular events triggered during progesterone-induced oocyte maturation in Xenopus are not well understood. One of the first events is the activation of the MAPK cascade and the maturation-promoting factor (MPF). The latter triggers meiosis I resumption and meiosis II progression until the metaphase II arrest. The release of the metaphase II is mediated by the anaphase-promoting complex (APC)-dependent degradation of cyclin B. This degradation activity requires the APC activator Cdc20 that activates ubiquitination reactions by recruiting substrates to the APC. However, recent reports in different organisms involve other APC regulators during different phases of the meiotic cycle. Therefore, we investigated the role of another APC regulator, XCdh1 during the G2/M transition in meiosis I in the Xenopus oocyte. Here, we report that XCdh1 protein is expressed in oocytes. Besides, injection of specific XCdh1 antisense inhibits progesterone-induced G2/M transition that can be rescued by adding back the purified human Cdh1 protein. On the other hand, ectopic expression of low levels of XCdh1 protein has a positive effect on the G2/M transition by facilitating this process. Moreover, the sole injection of XCdh1 mRNA triggers Mos p...Continue Reading

References

Jan 8, 2000·Developmental Biology·C Papin, J C Smith
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Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·K F CooperR Strich
Jan 9, 2001·Nature Cell Biology·M PeterJ C Labbé
Mar 17, 2001·Genesis : the Journal of Genetics and Development·T ChuS Strickland
Dec 4, 2001·Biology of the Cell·A CastroE Mandart
Apr 20, 2002·EMBO Reports·Anna CastroThierry Lorca
Jun 7, 2002·Molecular Cell·Jan-Michael Peters
Jun 11, 2002·Biochemical and Biophysical Research Communications·Yuan ZhouDong-Yan Jin
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Sep 23, 2003·Nature Cell Biology·Duncan J ClarkeSteven I Reed
Dec 6, 2003·The EMBO Journal·Claudine KraftJan-Michael Peters

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Citations

Aug 7, 2009·The Journal of Biological Chemistry·Yadushyla Narasimhachar, Martine Coué
Mar 8, 2005·The Journal of Reproduction and Development·Koji SugiuraHideaki Tojo
Apr 13, 2005·The Journal of Cell Biology·Jessica B CasalettoSally Kornbluth
Jan 8, 2008·The FEBS Journal·Catherine PapinElisabeth Mandart
Jul 5, 2008·Annual Review of Cell and Developmental Biology·Jillian A Pesin, Terry L Orr-Weaver
Oct 5, 2007·Reproductive Sciences·KilSoo KimYong-Pil Cheon

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