PMID: 9533652Apr 9, 1998Paper

Xenin--a review

Peptides
G E Feurle

Abstract

Xenin, a 25 amino acid peptide, has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin. Xenin is structurally related also to the hypothalamic and ileal peptide neurotensin and is, therefore, a member of the xenopsin/neurotensin/xenin peptide family. The biological activities of these peptides are similar: Xenin has been shown to inhibit pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. Radioimmunoassay and chromatography of postprandial plasma in humans indicate the release of xenin into the circulation. The identification of a 35-amino acid precursor peptide of xenin - proxenin, and a review of the Gen-bank revealed that xenin represents the N terminus of a cytosolic coat protein (alpha-COP) from which xenin can be cleaved by aspartic proteinases such as pepsin and cathepsin E. The physiological role of the peptide xenin is not known.

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Citations

Jul 23, 2003·Regulatory Peptides·Ramona A SilvestreJosé Marco
Jul 5, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G E FeurleG Hamscher
Apr 28, 2010·The Journal of Biological Chemistry·Burton M WiceKenneth S Polonsky
Oct 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sheng ZhangBurton M Wice
Jan 5, 2006·Respiratory Research·Alasdair J EdgarJulia M Polak
Aug 13, 2013·PLoS Genetics·Kim RoelantsFranky Bossuyt
Jul 6, 2010·Neuroscience Letters·Eun Ran Kim, Tooru M Mizuno
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Mar 6, 2015·Frontiers in Systems Neuroscience·Juliette A BrownGina M Leinninger
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M AnlaufG E Feurle
Jan 18, 2018·Molecular Biology Reports·Alexander T MaryanovichAndrey D Polyanovsky
Jan 25, 2017·The Journal of Pharmacology and Experimental Therapeutics·Izumi KajiJonathan D Kaunitz
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sara ChowdhuryBurton M Wice
Nov 2, 2019·Physiological Reviews·Amy C EngevikJames R Goldenring
Aug 1, 2018·Frontiers in Endocrinology·Jens F Rehfeld
Apr 13, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Atsukazu KuwaharaYoshinori Marunaka
Aug 17, 2020·Domestic Animal Endocrinology·T OnagaH Hayashi
Oct 10, 2020·Future Medicinal Chemistry·Andy Wai Kan YeungNikolay T Tzvetkov
Feb 19, 2021·Physiological Reports·Yuko KuwaharaAtsukazu Kuwahara
Apr 4, 2021·Nutrients·Van B LuFrank Reimann

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