PMID: 2504879Sep 1, 1989Paper

Xenogeneic skin graft rejection is especially dependent on CD4+ T cells

The Journal of Experimental Medicine
R N PiersonH Auchincloss

Abstract

B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.

References

Jan 1, 1977·Immunological Reviews·E Simpson, R D Gordon
Jan 1, 1989·Immunologic Research·H AuchinclossH J Winn
May 1, 1986·Transplantation·S Cobbold, H Waldmann
Aug 1, 1987·Transplantation·J Wheelahan, I F McKenzie
Oct 1, 1987·The Journal of Experimental Medicine·T IchikawaT Mori

❮ Previous
Next ❯

Citations

Mar 5, 2009·JAMA : the Journal of the American Medical Association·Richard N Pierson
Jan 1, 1997·Immunologic Research·T TakahashiJ L Platt
Dec 1, 1990·Immunology Today·J L PlattF H Bach
Aug 1, 1996·Immunology Today·W ParkerJ L Platt
Sep 1, 1994·Baillière's Clinical Gastroenterology·I J FoxB W Shaw
Oct 1, 1992·Current Opinion in Immunology·M D Pescovitz
Feb 4, 1998·Life Sciences·S Saadi, J L Platt
Mar 17, 1999·Transplantation Proceedings·J Kovarik, T E Mandel
Mar 22, 1997·Lancet·A DorlingR Lechler
Feb 15, 2000·The British Journal of Surgery·B SoinP J Friend
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H AuchinclossL H Glimcher
Dec 28, 1999·Transplantation·T UchidaH Yasui
Oct 3, 2000·Transplantation·S YiP J O'Connell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.