Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness

Transplantation
R BarthKazuhiko Yamada

Abstract

The potential of xenotransplantation for clinical application will require overcoming barriers of humoral and cellular rejection, through strategies using immune suppression or tolerance induction. This laboratory has previously reported the induction of tolerance in the discordant xenogeneic model of pig-to-rodent thymic transplantation. We also have described a miniature swine model of fully mismatched allogeneic composite vascularized thymokidney transplantation that induced transplantation tolerance. We tested a combination of these approaches in a clinically relevant pig-to-primate model of xenotransplantation. Composite thymokidney grafts were prepared 40 to 80 days before transplantation by the autologous implantation of thymic tissue under the renal capsule of human decay-accelerating factor transgenic swine. Baboons received xenotransplants of both human decay-accelerating factor composite thymokidneys and omental implants of thymic tissue. Recipients were treated with an immunosuppressive-conditioning regimen including thymectomy or thymic irradiation, extracorporeal immunoadsorption of anti-alphaGal antibodies and T-cell depletion. Recipients were followed for indicators of xenograft rejection, T-cell depletion and r...Continue Reading

References

Apr 24, 1987·Cell·J W KapplerP Marrack
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·L A LeeM Sykes
Jun 1, 1993·Immunological Reviews·A CoutinhoN Le Douarin
Sep 1, 1996·Kidney International·R B Colvin
Nov 1, 1996·Nature Medicine·Y ZhaoM Sykes
Dec 16, 1998·Xenotransplantation·D K Cooper
May 23, 1998·Annual Review of Immunology·H Auchincloss, D H Sachs
Mar 20, 1999·Transplantation Proceedings·A WuD H Sachs
Mar 20, 1999·Transplantation Proceedings·K YamadaD H Sachs
Mar 7, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C M VialJ J Dunning
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K YamadaD H Sachs
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·A ShimizuR B Colvin
Feb 18, 2003·Transplantation·Anette WuDavid H Sachs

❮ Previous
Next ❯

Citations

Aug 22, 2007·Cell Biochemistry and Biophysics·Prashanth VallabhajosyulaDavid H Sachs
Aug 23, 2003·Lancet·David K C Cooper
Dec 8, 2005·Nature Medicine·David H Sachs
Jun 16, 2007·Nature Reviews. Immunology·Yong-Guang Yang, Megan Sykes
Jun 18, 2010·Transplantation·Adam D GriesemerMark A Hardy
Nov 25, 2011·Journal of the American Society of Nephrology : JASN·Akira ShimizuRobert B Colvin
Mar 5, 2005·Médecine sciences : M/S·Céline SévenoBernard Vanhove
Apr 21, 2010·Expert Review of Clinical Immunology·Burcin Ekser, David K C Cooper
Jan 28, 2016·Xenotransplantation·David K C CooperRita Bottino
Jun 6, 2012·Transplantation Proceedings·D ZhaoL Hong
Dec 9, 2008·Transplant Immunology·David H SachsKazuhiko Yamada
Oct 29, 2008·Transplant Immunology·Burcin EkserDavid K C Cooper
Aug 27, 2015·International Journal of Surgery·Laura HigginbothamAndrew B Adams
Feb 14, 2004·Xenotransplantation·Leo Buhler
Jul 20, 2006·Clinical Transplantation·Akira Shimizu, Kazuhiko Yamada
Feb 13, 2014·Immunological Reviews·Adam GriesemerMegan Sykes
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D GriesemerK Yamada
Mar 29, 2007·PLoS Medicine·Muhammad M Mohiuddin
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kiyoshi Ogata, Jeffrey L Platt
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sonja SchrepferHermann Reichenspurner
Dec 23, 2016·Cold Spring Harbor Perspectives in Biology·Sean Stevens
Dec 12, 2018·Xenotransplantation·Jeffrey L PlattMarilia Cascalho
Dec 13, 2018·ILAR Journal·Jeffrey L PlattJorge A Piedrahita
Jul 29, 2005·Journal of the American Society of Nephrology : JASN·Akira ShimizuRobert B Colvin
Nov 5, 2019·Science Immunology·Megan Sykes, David H Sachs
Feb 1, 2007·Current Opinion in Organ Transplantation·Peter J CowanAnthony Jf dʼApice
Nov 1, 2018·Current Opinion in Organ Transplantation·Nathaly P LloreAdam Griesemer
Jul 2, 2009·Organogenesis·Emanuele CozziErmanno Ancona
Aug 28, 2020·Pediatric Transplantation·Mohamed BikhetHayato Iwase
Jul 13, 2017·Molecular Biotechnology·Magdalena HryhorowiczDaniel Lipiński
Mar 5, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hannes KalscheuerMegan Sykes
Mar 15, 2020·Xenotransplantation·Angela M Chen, Christopher Burlak
Nov 22, 2017·Journal of Immunology Research·Kannan P SamyBurcin Ekser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.