Xenogeneic transplantation

Annual Review of Immunology
H Auchincloss, D H Sachs

Abstract

This review summarizes the clinical history and rationale for xenotransplantation; recent progress in understanding the physiologic, immunologic, and infectious obstacles to the procedure's success; and some of the strategies being pursued to overcome these obstacles. The problems of xenotransplantation are complex, and a combination of approaches is required. The earliest and most striking immunologic obstacle, that of hyperacute rejection, appears to be the closest to being solved. This phenomenon depends on the binding of natural antibody to the vascular endothelium, fixation of complement by that antibody, and finally, activation of the endothelium and initiation of coagulation. Therefore, these three pathways have been targeted as sites for intervention in the process. The mechanisms responsible for the next immunologic barrier, that of delayed xenograft/acute vascular rejection, remain to be fully elucidated. They probably also involve multiple pathways, including antibody and/or immune cell binding and endothelial cell activation. The final immunologic barrier, that of the cellular immune response, involves mechanisms that are similar to those involved in allograft rejection. However, the strength of the cellular immune ...Continue Reading

References

Dec 1, 1991·Transplantation·J L Platt, F H Bach
Jun 1, 1991·Annals of Internal Medicine·M H SayeghN L Tilney
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K GustafssonD H Sachs
Apr 1, 1990·The Journal of Experimental Medicine·J L PlattA P Dalmasso
Jun 1, 1990·Human Immunology·D H Sachs, F H Bach
Jan 1, 1990·The Journal of Experimental Medicine·B J Alter, F H Bach
Sep 1, 1989·The Journal of Experimental Medicine·R N PiersonH Auchincloss
Jul 1, 1988·Transplantation·H Auchincloss
Jul 3, 1969·Annals of the New York Academy of Sciences·K Reemtsma
Sep 1, 1965·Annals of Surgery·B EisemanF Raffucci
Nov 30, 1995·The New England Journal of Medicine·L E ChapmanP D Noguchi
May 1, 1995·The Journal of Experimental Medicine·M H SayeghL A Turka
Sep 1, 1995·Nature Medicine·D H SachsA B Cosimi
Oct 1, 1994·Veterinary Immunology and Immunopathology·D H Sachs
Oct 1, 1994·Immunological Reviews·M SykesD H Sachs
Nov 15, 1994·Transplantation·J C GerlachP Neuhaus
Jan 9, 1993·Lancet·T E StarzlM Michaels

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Citations

Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Roger A Barker
Sep 13, 2001·Molecular Reproduction and Development·K BondioliW Fodor
Feb 3, 2007·Journal of Applied Genetics·Eduardo O MeloRodolfo Rumpf
Aug 8, 2013·Current Diabetes Reports·Philip J O'ConnellAndrew M Lew
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Johannes WaiserHans-Hellmut Neumayer
Apr 1, 2004·The Surgical Clinics of North America·Ruediger Hoerbelt, Joren C Madsen
Jan 3, 2001·Transplantation Proceedings·E CozziD White
May 16, 2002·Transplantation Proceedings·Antonio VegaG Pino-Chavez
Mar 15, 2000·Transplantation Proceedings·G L XiaM Waer
Dec 25, 2002·Theriogenology·R S PratherJ L Greenstein
Jan 17, 2002·Molecular Immunology·Yukari Motegi-IshiyamaYohtaroh Takagaki
Aug 14, 2003·Molecular Immunology·Tom E Mollnes, Arnt E Fiane
Jul 14, 1999·Molecular Immunology·T E Mollnes, A E Fiane
Jun 20, 2002·Veterinary Immunology and Immunopathology·Jan HolgerssonLena Serrander
Sep 5, 2002·Veterinary Immunology and Immunopathology·Ana CarrilloJosé Yélamos
Jan 19, 2000·Immunology Today·R M Smith, T E Mandel
Oct 13, 2001·Trends in Cardiovascular Medicine·D A CunninghamG A Langford
Jul 10, 2003·Lancet Neurology·Anders BjörklundRoger Barker
Jul 30, 2002·Allergy·Tom Eirik Mollnes, A E Fiane
Feb 24, 2001·Xenotransplantation·J D SeebachD H Sachs
Mar 22, 2002·Nature Reviews. Immunology·M Cascalho, J L Platt
Dec 24, 2002·Nature Medicine·Benjamin DekelYair Reisner
Oct 4, 2003·Nature Reviews. Genetics·John Clark, Bruce Whitelaw
Sep 22, 2005·Nature Reviews. Immunology·Robert B Colvin, R Neal Smith
Dec 14, 1999·The British Journal of Surgery·S A White, M L Nicholson
Feb 15, 2000·The British Journal of Surgery·B SoinP J Friend
Jul 6, 2001·Scandinavian Journal of Immunology·M K SchneiderJ D Seebach
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stanislava UhrinovaPaul N Barlow
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria F PerdomoAnders Vahlne
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rutger-Jan SwijnenburgJoseph C Wu

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Methods Mentioned

BETA
xenograft
xenografting
xenografts
transgenic
genetic

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