Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.

Mitochondrion
Matthew V CannonCarl A Pinkert

Abstract

Xenomitochondrial mice, harboring evolutionarily divergent Mus terricolor mitochondrial DNA (mtDNA) on a Mus musculus domesticus nuclear background (B6NTac(129S6)-mt(M. terricolor)/Capt; line D7), were subjected to molecular and phenotypic analyses. No overt in vivo phenotype was identified in contrast to in vitro xenomitochondrial cybrid studies. Microarray analyses revealed differentially expressed genes in xenomitochondrial mice, though none were directly involved in mitochondrial function. qRT-PCR revealed upregulation of mt-Co2 in xenomitochondrial mice. These results illustrate that cellular compensatory mechanisms for mild mitochondrial dysfunction alter mtDNA gene expression at a proteomic and/or translational level. Understanding these mechanisms will facilitate the development of therapeutics for mitochondrial disorders.

References

May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·C L BunnJ M Eisenstadt
Jul 1, 1997·American Journal of Human Genetics·N Howell
Mar 5, 1999·Science·D C Wallace
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J E SlighD C Wallace
Oct 25, 2001·Journal of Molecular Evolution·A Eyre-Walker, P Awadalla
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Carl A Pinkert, Ian A Trounce
Dec 7, 2002·The Biochemical Journal·Rodrigue RossignolThierry Letellier
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthew McKenzieCarl A Pinkert
Sep 21, 2004·Journal of Bioenergetics and Biomembranes·I A TrounceC A Pinkert
Nov 27, 2004·Journal of Cell Science·Jochen HessMarina Schorpp-Kistner
Oct 6, 2005·Respiratory Physiology & Neurobiology·C BordayG Fortin
Nov 10, 2005·Biochimica Et Biophysica Acta·Andrew J TompkinsPaul S Brookes
May 24, 2006·Progress in Neurobiology·Gennadij Raivich, Axel Behrens
Nov 8, 2006·Neuron·Anastassios V Tzingounis, Roger A Nicoll
Dec 1, 2006·Trends in Neurosciences·Daniel Lévesque, Claude Rouillard
Feb 26, 2008·Trends in Cell Biology·Vladimir GogvadzeBoris Zhivotovsky

❮ Previous
Next ❯

Citations

Jun 13, 2013·Trends in Genetics : TIG·G Jane FarrarSophia Millington-Ward
Apr 26, 2014·PLoS Genetics·Patrick F ChinneryDouglass M Turnbull
Oct 16, 2012·Current Opinion in Genetics & Development·Patrick NarbonneJ B Gurdon
Aug 23, 2011·Biochimica Et Biophysica Acta·David A DunnCarl A Pinkert
Sep 22, 2012·Molecular Ecology·Ronald S Burton, Felipe S Barreto
Apr 8, 2015·Drug Development Research·Matthew V CannonCarl A Pinkert
Aug 19, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Léo DeremiensBernard Angers
Oct 13, 2012·Communicative & Integrative Biology·Patrick NarbonneJ B Gurdon
Jan 22, 2013·Neurobiology of Disease·Guomei TangDavid Sulzer
Mar 1, 2012·Pharmacology, Biochemistry, and Behavior·Kodeeswaran ParameshwaranCarl A Pinkert
Nov 27, 2014·Molecular Human Reproduction·Joerg Patrick BurgstallerJoanna Poulton
Jun 28, 2017·Human Reproduction Update·Lyndsey CravenBjörn Heindryckx
Aug 3, 2011·Reproductive Medicine and Biology·Matthew V CannonCarl A Pinkert
Jul 29, 2017·Stem Cells International·Andrés CaicedoMaroun Khoury

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.