Xenon improves recovery from myocardial stunning in chronically instrumented dogs.

Anesthesia and Analgesia
Maike A Grosse HartlageThomas P Weber

Abstract

In this study we tested the hypothesis that inhalational administration of xenon improves recovery from myocardial stunning. Ten dogs were chronically instrumented for measurement of heart rate; left atrial, aortic, and left ventricular pressure; coronary blood-flow velocity; and myocardial wall-thickening fraction. Regional myocardial blood flow was determined with fluorescent microspheres. Catecholamine plasma levels were measured by high-performance liquid chromatography. An occluder around the left anterior descending artery (LAD) allowed the induction of a reversible LAD ischemia. Animals underwent 2 experimental conditions in a randomized crossover fashion on separate days: (a) 10 min of LAD occlusion under fentanyl (25 microg. kg(-1). h(-1)) and midazolam (0.6 mg. kg(-1). h(-1)) (control) and (b) a second ischemic episode under the same basal anesthesia with concomitant inhalational administration of 75 +/- 1 vol% xenon (intervention). Anesthesia was induced 35 min before LAD occlusion and was discontinued after 20 min of reperfusion. Dogs receiving xenon showed a significantly better recovery of wall-thickening fraction up to 12 h after ischemia. The increase in plasma epinephrine during emergence from anesthesia and in...Continue Reading

References

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Citations

Jan 7, 2010·European Journal of Anaesthesiology·Christian SchwiebertBenedikt Preckel
Sep 27, 2006·Anesthesia and Analgesia·Maike A Grosse HartlageThomas P Weber
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Benedikt Preckel, Wolfgang Schlack
Mar 22, 2012·Critical Care Clinics·Matthias Derwall, Michael Fries
Jul 30, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·O DelhayeB Vallet
Apr 14, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Jan H BaumertRolf Rossaint
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hélène N DavidJacques H Abraini
May 29, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H ZhaoD Ma
Feb 21, 2016·Pharmacology & Therapeutics·David A WinklerIra Katz
Oct 16, 2015·Critical Care : the Official Journal of the Critical Care Forum·Thomas BreuerChristian Stoppe
Sep 14, 2011·Transplantation Proceedings·H J WilkeK Zacharowski
Mar 18, 2008·British Journal of Anaesthesia·J-H BaumertR Rossaint
Mar 15, 2006·Current Opinion in Anaesthesiology·Robert D Sanders, Mervyn Maze
Apr 18, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Paola Elvira MocaveroAntonio Corcione
Feb 26, 2020·Intensive Care Medicine Experimental·Roehl AnnaCoburn Mark

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