journal cover

Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells

Life Sciences

Nov 9, 2010

John P M WhiteI Nagy

Abstract

Xenon provides effective analgesia in several pain states at sub-anaesthetic doses. Our aim was to examine whether xenon may mediate its analgesic effect, in part, through reducing the activity of transient receptor potential vanilloid type 1 (TRPV1), a receptor known to be involved in ...read more

Mentioned in this Paper

Embryo
Transfection
Annexin A5
HEK293 Cells
Glycerin
Dimethyl Sulfoxide
Immunohistochemistry
Formalin
MAPK3 wt Allele
Structure of Posterior Gray Horn of Spinal Cord
Paper Details
References
  • References32
  • Citations2
1234
  • References32
  • Citations2
1

Similar Papers Found In These Feeds

NMDA Receptor Signaling

The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.

Transverse Myelitis

Transverse myelitis is inflammation of the entire width of the spinal cord. It presents as motor, sensory, or autonomic dysfunction. The cause is not known, but it has been associated with various infections, immune disorders, and demyelination. Find the latest research on transverse myelitis here.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Phosphoproteomics

Phosphoproteomics refers to the identification and quantification of phosphorylated proteins in the proteome. This approach provides a high-throughput method of examining the state of intracellular phosphorylation. Here is the latest research on phosphoproteomics.

Neuronal Cell Types

There are diverse ranges of neurons, which are defined by their structural, functional, connectional and molecular properties. For example, some type of neurons includes sensory, sympathetic, and motor neurons. Discover the latest research on neuronal cell types here.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Organellar TRP channels

Orangellar TRP channels are transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. Discover the latest research on organellar TRP channels here.

Pain Signaling

Pain signaling pathways involve many molecular components that could potentially be targets for pharmacotherapeutic interventions. Discover the latest research on nociception and signal transduction through nocireceptors here.

Selective Ion Transport in Channels & Pumps

Ion channels and pumps are central to a number of cell functions, including membrane excitability and synaptic transmission. With sophisticated imaging, these channels and pumps have been characterized as selective for the ions, sodium, potassium chloride and calcium. Here is the latest research on selection ion transport in channels and pumps.

Penicillins

Penicillin is a group of antibiotics that can be administered intravenously or intramuscularly to treat bacterial infections caused by staphylococci and streptococci. While they are still widely used today, many bacteria have developed resistance to penicillin. Here is the latest research on penicillins.

Pain & Addiction

Chronic pain and addictive disorders present significant medical and public health problems; both are underdiagnosed and inadequately treated. The cooccurrence of pain and addiction adds complexity to the assessment and treatment of both disorders. Discover the latest reserch on pain and addiction here.

Spinal Cord Neoplasms

Spinal cord neoplasms affect the spinal cord and arise from either within the spinal cord or from extramedullary structures that surround the spinal cord. The cancer can arise from different cell types such as the meninges surrounding the spinal cord, glial or nerve cells within the CNS. Here is the latest research on spinal cord neoplasms.

Lichtheim's Disease

Lichtheim's disease or subacute combined degeneration of spinal cord is a degenerative disease associated with deficiencies in vitamin B12, vitamin E, and copper. Here is a latest research.

Related Papers

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie

Xenon does not reduce opioid requirement for orthopedic surgery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésieDecember 31, 2004
M LuginbühlT W Schnider
© 2020 Meta ULC. All rights reserved

Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells

Life Sciences

Nov 9, 2010

John P M WhiteI Nagy

PMID: 21056583

DOI: 10.1016/j.lfs.2010.11.002

Abstract

Xenon provides effective analgesia in several pain states at sub-anaesthetic doses. Our aim was to examine whether xenon may mediate its analgesic effect, in part, through reducing the activity of transient receptor potential vanilloid type 1 (TRPV1), a receptor known to be involved in ...read more

Mentioned in this Paper

Embryo
Transfection
Annexin A5
HEK293 Cells
Glycerin
Dimethyl Sulfoxide
Immunohistochemistry
Formalin
MAPK3 wt Allele
Structure of Posterior Gray Horn of Spinal Cord

Similar Papers Found In These Feeds

NMDA Receptor Signaling

The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.

Transverse Myelitis

Transverse myelitis is inflammation of the entire width of the spinal cord. It presents as motor, sensory, or autonomic dysfunction. The cause is not known, but it has been associated with various infections, immune disorders, and demyelination. Find the latest research on transverse myelitis here.

Related Papers

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie

Xenon does not reduce opioid requirement for orthopedic surgery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésieDecember 31, 2004
M LuginbühlT W Schnider
Paper Details
References
  • References32
  • Citations2
1234
  • References32
  • Citations2
1
/papers/xenon-reduces-activation-of-transient-receptor/21056583