PMID: 9533956May 12, 1998Paper

Xenopus cadherin-11 (Xcadherin-11) expression requires the Wg/Wnt signal

Mechanisms of Development
B HadeballD Wedlich

Abstract

In this study we describe the isolation of Xcadherin-11, the Xenopus homologue to the mesenchymal cadherin-11. Similar to epithelial and neural cadherins, overexpression of Xcadherin-11 led to posteriorised phenotypes due to inhibition of convergent extension movement. Because zygotic expression of Xcadherin-11 starts with gastrulation, we analysed the ability of different growth factors involved in mesoderm differentiation to induce the expression of Xcadherin-11. Using the animal cap assay, we demonstrated that Xcadherin-11 is activated by Xwnt-8 or beta-catenin, but repressed by BMP-4. Activin did not induce Xcadherin-11 but its synergistic function was required for the Xwnt-8/beta-catenin-mediated activation of Xcadherin-11. Because Xcadherin-11 and Xenopus E- and N-cadherin are differentially regulated by growth factors in the Xenopus animal cap, our results also reveal that this assay provides a helpful model system to elucidate the molecular control mechanism of epithelial-mesenchymal conversion.

References

Jan 1, 1986·Developmental Biology·R E Keller
May 1, 1995·Cell Adhesion and Communication·L SimonneauJ P Thiery
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
May 1, 1995·Developmental Biology·I Hoffmann, R Balling
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T S JouJ A Marrs
Aug 1, 1994·Cell Adhesion and Communication·J Stappert, R Kemler
Feb 1, 1994·Current Biology : CB·J M Slack
Sep 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Lemaire, J B Gurdon
Jul 1, 1994·The Journal of Cell Biology·W M Brieher, B M Gumbiner
Jan 1, 1993·Annual Review of Cell Biology·C Birchmeier, W Birchmeier
Feb 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R T Moon
Oct 1, 1995·Current Opinion in Cell Biology·B M Gumbiner
Aug 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y KimuraM Takeichi
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Kühl, D Wedlich
Oct 1, 1996·Current Opinion in Cell Biology·O HuberR Kemler
Feb 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Kühl, D Wedlich
May 2, 1997·The Journal of Biological Chemistry·S FinnemannD Wedlich
Mar 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Makoto AsashimaNaoto Ueno

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Citations

Aug 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tatsuo OhiraHarry A Drabkin
Oct 24, 2008·Molecular Biology of the Cell·Catherine McCuskerDominique Alfandari
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R KellerP Skoglund
Jan 17, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sei Kuriyama, Roberto Mayor
Dec 28, 1999·Annual Review of Cell and Developmental Biology·C LaBonne, M Bronner-Fraser
Feb 18, 2016·Developmental Biology·Chaolie HuangJubin Kashef
May 12, 2012·Seminars in Cancer Biology·Pablo H Strobl-Mazzulla, Marianne E Bronner
Mar 10, 2016·Nature Communications·Rahul P LangheJubin Kashef
Jul 24, 2004·The EMBO Journal·Araceli MedinaHerbert Steinbeisser
Mar 21, 2012·Seminars in Cell & Developmental Biology·Laura Kerosuo, Marianne Bronner-Fraser
Sep 23, 2008·Biochemical and Biophysical Research Communications·Yan Zhou, Malcolm L Snead
Jun 5, 2010·Cell Adhesion & Migration·Abha J ChalpeAlicia F Paulson
Feb 15, 2014·Cell Adhesion & Migration·Alicia F PaulsonPasquale Manzerra
Jan 18, 2003·Developmental Cell·Neil A HukriedeIgor B Dawid
Nov 6, 2012·Developmental Biology·Sonja J McKeownRichard B Anderson
Aug 29, 2009·Developmental Biology·Shuyi NieMarianne Bronner-Fraser
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Husniye KantarciBruce B Riley
Mar 3, 2017·Genesis : the Journal of Genetics and Development·Lisa A Taneyhill, Andrew T Schiffmacher
May 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T GotoH Y Kubota
Feb 6, 2015·Journal of Korean Medical Science·Tae-Hyung KimJang Won Sohn
Jun 5, 2008·Nature Reviews. Molecular Cell Biology·Tatjana Sauka-Spengler, Marianne Bronner-Fraser
Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M BaltzingerP Remy
Jul 9, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K KitajimaT Nakamura
Oct 22, 2010·Cell Adhesion & Migration·Michael W KlymkowskyKristin Bruk Artinger
Jul 20, 1999·Molecular and Cellular Biology·D GradlD Wedlich
Jul 4, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuji KiyamaToshiya Manabe
Nov 17, 2020·Frontiers in Physiology·Subrajaa ManoharCrystal D Rogers
Aug 6, 2013·Molecular Cancer Research : MCR·Yu-Chen LeeSue-Hwa Lin
Nov 20, 2003·Journal of Cell Science·Beate K StraubWerner W Franke
Oct 28, 2008·Development·Matthias Hammerschmidt, Doris Wedlich
Mar 6, 2012·Archives of Biochemistry and Biophysics·Sarah F BeckerJubin Kashef

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