PMID: 6169009Aug 11, 1981Paper

Xenopus laevis serum albumins are encoded in two closely related genes

Nucleic Acids Research
B WestleyR Weber

Abstract

cDNA clones containing sequences complementary to Xenopus laevis albumin mRNA have been identified in a collection of cDNA clones made from poly(A)+ RNA prepared from male Xenopus laevis liver. Although all the albumin cDNA clones crosshybridise, restriction enzyme and heteroduplex analysis show that there are 2 closely related albumin mRNA sequences. The 2 albumin mRNAs are only mismatched by 8% but could be isolated by positive selection using stringent hybridization conditions. Oocytes injected with the 2 purified mRNAs, secreted either the 68,000 or 74,000 dalton albumin into the culture medium showing that the 2 albumins of X. laevis serum are encoded in the 2 closely related mRNAs. Measurements of the abundance of albumin mRNA show that the 2 albumin mRNAs together account for about 9% of total poly(A)+ RNA in male Xenopus laevis liver but the mRNA coding for the 74,000 dalton mRNA is about twice as abundant as that coding for the 68,000 dalton mRNA.

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Citations

Dec 1, 1986·Biochemical Genetics·J D Graf, M Fischberg
Mar 1, 1986·Molecular and Cellular Endocrinology·A T RiegelD R Schoenberg
Jan 1, 1987·Molecular and Cellular Endocrinology·L J Holland, L J Wangh
Dec 18, 2001·Brain Research. Molecular Brain Research·W H van den HurkG J Martens
Jan 24, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M A BrownP Licht
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W WahliF E May
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J KnowlandW Wahli
Dec 20, 1982·Nucleic Acids Research·R K PatientJ G Williams
Jun 25, 1983·Nucleic Acids Research·F E MayH Diggelmann
Dec 21, 1981·Nucleic Acids Research·D R Schoenberg
Apr 6, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Victoria J MetcalfStephen O Brennan
Aug 5, 1983·Journal of Molecular Biology·F E MayR Weber
Aug 1, 1990·Differentiation; Research in Biological Diversity·A PötingW Knöchel
May 4, 2001·Mechanisms of Development·A M Zorn, J Mason
Dec 2, 2005·Neuroendocrinology·Dorien M de GrootGerard J M Martens
Nov 1, 1982·The Journal of Experimental Zoology·J Wolff, H R Kobel
Dec 30, 2011·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Yoon-Seok RohBumseok Kim
Nov 10, 1988·Biochimica Et Biophysica Acta·R W OldA R Brooks
Nov 1, 1984·Molecular and Cellular Biology·L J Holland, L J Wangh
Oct 1, 1984·Experimental Cell Research·A P WolffeJ R Tata
Jan 1, 1982·Differentiation; Research in Biological Diversity·B Westley, R Weber

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