Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling

Developmental Cell
Takayuki OnaiYoshiki Sasai

Abstract

Here we show that XsalF, a frog homolog of the Drosophila homeotic selector spalt, plays an essential role for the forebrain/midbrain determination in Xenopus. XsalF overexpression expands the domain of forebrain/midbrain genes and suppresses midbrain/hindbrain boundary (MHB) markers and anterior hindbrain genes. Loss-of-function studies show that XsalF is essential for the expression of the forebrain/midbrain genes and for the repression of the caudal genes. Interestingly, XsalF functions by antagonizing canonical Wnt signaling, which promotes caudalization of neural tissues. XsalF is required for anterior-specific expressions of GSK3beta and Tcf3, genes encoding antagonistic effectors of Wnt signaling. Loss-of-function phenotypes of GSK3beta and Tcf3 mimic those of XsalF while injections of GSK3beta and Tcf3 rescue loss-of-function phenotypes of XsalF. These findings suggest that the forebrain/midbrain-specific gene XsalF negatively controls cellular responsiveness to posteriorizing Wnt signals by regulating region-specific GSK3beta and Tcf3 expression.

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Citations

Dec 5, 2006·Oncogene·C GuderT W Holstein
Jul 14, 2009·PloS One·J Susie ZoltewiczAndrew S Peterson
Nov 28, 2015·Zoological Letters·Takayuki OnaiShigeru Kuratani
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Dec 4, 2016·Developmental Biology·Gun-Sik ChoJin-Kwan Han
Apr 13, 2018·EvoDevo·José Lorente-SorollaCristina Grande
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Jun 27, 2009·Developmental Biology·Daniel D RocheAnne H Monsoro-Burq

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