PMID: 8581406Sep 1, 1995Paper

Xenoreactive natural antibodies in the world of natural antibodies: typical or unique?

Transplant Immunology
W ParkerJ L Platt

Abstract

Xenoreactive natural antibodies are thought to be responsible for initiating the hyperacute rejection of porcine organs transplanted into primates. Progress has been made in recent years in the characterization of the specificity and functions of these antibodies. Xenoreactive natural antibodies recognize Gal alpha 1-3Gal, a carbohydrate related to the blood group A and blood group B antigens. The presence of Gal alpha 1-3Gal may not be sufficient to allow the binding of xenoreactive natural antibodies under physiological conditions; rather, the clustering of Gal alpha 1-3Gal determinants may dictate the extent to which xenoreactive natural antibodies attach to surfaces on which Gal alpha 1-3Gal is expressed. The predominant role of xenoreactive natural antibodies in the pathogenesis of hyperacute rejection in porcine-to-primate xenotransplantation involves the activation of complement. Complement activation is mediated by IgM, not IgG xenoreactive natural antibodies. Based on functional avidity, thermal binding optima, thermal liability and homogeneity of binding interactions, xenoreactive natural IgM appear to be members of a family of natural antibodies which includes isohaemagglutinins. The classification of xenoreactive an...Continue Reading

References

Jan 17, 1975·Science·F F RichardsJ M Varga
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Apr 1, 1992·The Journal of Clinical Investigation·R M HamadehJ M Griffiss
Dec 1, 1991·Transplantation·J L Platt, F H Bach
Apr 1, 1990·The Journal of Experimental Medicine·J L PlattA P Dalmasso
May 1, 1990·Immunology Today·K BendtzenE Hippe
May 1, 1990·Transplantation·J L PlattF H Bach
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·U GaliliB A Macher
Aug 1, 1989·Immunological Reviews·A Coutinho
Feb 1, 1989·Journal of the National Cancer Institute·U Galili, B A Macher
Dec 1, 1988·Transplantation·S MiyagawaH Kitamura
Jul 1, 1988·Transplantation·H Auchincloss
Feb 1, 1986·British Journal of Haematology·U GaliliE A Rachmilewitz
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R W RosensteinF F Richards
Jul 1, 1969·The Journal of Clinical Investigation·G F Springer, R E Horton
Jan 1, 1966·Advances in Immunology·S V Boyden
Jul 1, 1966·Transplantation·R J Perper, J S Najarian
Mar 1, 1983·Journal of Surgical Oncology·D J CameronJ A Majeski
Jan 1, 1983·Springer Seminars in Immunopathology·W D RatnoffK F Austen
Nov 1, 1984·The Journal of Experimental Medicine·U GaliliI Flechner
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M M KayV Rudloff
Mar 1, 1981·British Journal of Haematology·G F Springer, H Tegtmeyer
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M S SandrinI F McKenzie
Nov 1, 1995·The Journal of Clinical Investigation·J C MageeJ L Platt
Jun 15, 1995·Transplantation·C G AlvaradoJ L Platt
Jan 15, 1995·Transplantation·R J KaplonJ L Platt
Feb 1, 1994·Transplantation·J L Platt, Z E Holzknecht
Apr 1, 1993·Current Opinion in Immunology·M E Goldberg, L Djavadi-Ohaniance

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Citations

Jan 1, 1997·Immunologic Research·T TakahashiJ L Platt
Jul 1, 1997·Human Immunology·T C RodmanR Winston
Aug 10, 1999·Human Immunology·T C RodmanR Winston
Jun 13, 2002·Xenotransplantation·Svend Kirkeby, Dennis Moe
Mar 27, 2001·Immunology and Cell Biology·S Kirkeby, D Moe
Jul 22, 2005·Immunology and Cell Biology·William Parker, Aaron P Lesher
Mar 26, 2005·Journal of Clinical Pathology·P A J KrijnenC E Hack
Feb 4, 1998·Life Sciences·S Saadi, J L Platt
Jan 20, 2000·Current Medical Research and Opinion·E O SchraaJ N IJzermans
Aug 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christine L LauR Duane Davis
Feb 17, 2015·Immunology Letters·Marketa HamanovaJindrich Lokaj
Feb 17, 1997·The Journal of Experimental Medicine·J YuS Tomlinson
Aug 12, 2020·Journal of the American Society of Nephrology : JASN·R John CrewS Ali Husain

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