Xeroderma pigmentosum group D haplotype predicts for response, survival, and toxicity after platinum-based chemotherapy in advanced nonsmall cell lung cancer

Cancer
Richard BootonNicholas Thatcher

Abstract

The treatment of lung cancer has reached a therapeutic plateau. Several mechanisms of platinum resistance have been described, including the removal of platinum-DNA adduct by nucleotide excision repair (NER). Polymorphisms within the Xeroderma pigmentosum Group D protein (XPD), a member of the NER pathway, are associated with alterations in enzyme activity and may change sensitivity to platinum-based chemotherapy. The authors investigated the relation between XPD polymorphisms and treatment response, toxicity, and overall survival in patients who received platinum-based chemotherapy for advanced nonsmall cell lung cancer (NSCLC). Between 2001 and 2002, 108 patients with chemotherapy-naive, advanced NSCLC were recruited. Associations between XPD312/751 polymorphisms and XPD haplotype and treatment response, toxicity. and survival were evaluated. Significant correlations were observed between XPD haplotype and Grade 4 neutropenia and overall survival together with a greater response to platinum-based chemotherapy for the XPD *A haplotype. The XPD haplotype may represent a useful pharmacogenomic marker of platinum-based chemotherapy in patients with advanced NSCLC and requires prospective validation.

References

May 16, 1998·Genome Research·D GordonP Green
Mar 10, 2001·Nature·R SachidanandamUNKNOWN International SNP Map Working Group
Jun 19, 2001·Mutation Research·M Kartalou, J M Essigmann
Jun 19, 2001·Mutation Research·M Kartalou, J M Essigmann
Nov 10, 2001·Annual Review of Genomics and Human Genetics·P Y Kwok
Dec 6, 2001·Nature Reviews. Genetics·A C Syvänen
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Sep 19, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Viktor Brabec, Jana Kasparkova
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G V ScagliottiUNKNOWN Italian Lung Cancer Project
Nov 25, 2003·Nature Reviews. Genetics·David B GoldsteinSanjay M Sisodiya
Jan 8, 2004·British Journal of Cancer·S Marsh, H L McLeod
May 14, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeong-Seon RyuTae-Sook Hwang
Jun 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarada GurubhagavatulaDavid C Christiani
Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Z HuH Shen

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Citations

Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanlong Yang, Lei Xian
May 29, 2010·Journal of Cancer Research and Clinical Oncology·Mary A BewickMichael S C Conlon
May 16, 2009·Expert Opinion on Drug Metabolism & Toxicology·Michelle A T HildebrandtXifeng Wu
Nov 17, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasunori SatoTomohide Tamura
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·W Jeffrey PettyAntonius A Miller
Oct 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Richard BootonNick Thatcher
Apr 21, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiaojing XuZhaoqian Liu
Apr 14, 2009·Clinical Lung Cancer·Aristea KalikakiDimitris Mavroudis
Jan 22, 2013·International Journal of Cancer. Journal International Du Cancer·Xicheng SongGuojun Li
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ming YinQingyi Wei
Dec 17, 2014·Pharmacogenomics·Virginia BosóSalvador F Aliño
Jul 15, 2017·The International Journal of Biological Markers·Sílvia SoaresRui Medeiros
Dec 29, 2010·Molecular Biology Reports·Dorota ButkiewiczMieczysław Chorąży

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