Xiao chai hu tang inhibits CVB1 virus infection of CCFS-1 cells through the induction of Type I interferon expression

International Immunopharmacology
Pei-Wen ChengChun-Ching Lin

Abstract

Coxsackie B virus type 1 (CVB1) infection is known to cause high morbidity and mortality in children, however, there is no effective drug for treating this disease. The present study aimed to examine the antiviral activity of xiao chai hu tang (XCHT), a popular herbal drug for treating viral and bacterial infections, against CVB1 infection and its mechanisms of action. Our data showed that XCHT neutralized the CVB1-induced cytopathic effect in human neonatal foreskin fibroblast cell line (CCFS-1/KMC), with IC50 (virus-induced cytopathic effect by 50%) and EC50 (concentration of 50% effectiveness) values around 12.39 and 50.93 microg/ml, respectively. Its CC50 (concentration of 50% cellular cytotoxicity) and SI (selective index) values were 945.75 microg/ml and 18.92, respectively. These results suggest that XCHT possessed anti-CVB1 activity, and showed no effect on CCFS-1 cell viability and growth at concentration 250 microg/ml. The time-of-addition studies showed that XCHT (50, 100 and 200 microg/ml) added at various time of preinfection (-1 to -3 h), coinfection (0 h) and postinfection (1 approximately 3 h) could inhibit CVB1 infection. Interestingly, XCHT also showed an inhibition on viral replication through the induction o...Continue Reading

References

Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·K OnoF Barré-Sinoussi
Mar 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·K OkitaM Takahashi
Feb 1, 1997·The Journal of General Virology·D N GalbraithG B Clements
Jan 1, 1997·Immunology·B H KroesR P Labadie
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YamashikiY Kosaka
Jun 9, 1997·Biochemical and Biophysical Research Communications·I M FrancischettiB Francischetti
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A I RamsinghS Tracy
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I ShimizuS Ito
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Apr 26, 2001·The American Journal of Chinese Medicine·J A WuC S Yuan
Jun 22, 2002·Antiviral Research·L C ChiangC C Lin
Nov 25, 2003·Anesthesia and Analgesia·Tz-Chong ChouShih-Ping Yang
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zenei TairaYukari Ueda
Jul 14, 2004·Circulation·Raj DeonarainEleanor N Fish
Dec 14, 2004·Journal of Ethnopharmacology·Haw-Yaw YoungWen-Huang Peng
Jan 22, 2005·European Journal of Pharmacology·Nobuhiro OhtakeMakoto Inoue
Jan 25, 2005·Acta Pharmacologica Sinica·Yong ChengJun-Tian Zhang
Aug 6, 2005·Biochemical and Biophysical Research Communications·Eok-Cheon KimYoung-Guen Kwon
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Hae-Ung LeeDong-Hyun Kim

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Citations

Jul 16, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ningning ZhengShuang Huang
May 30, 2014·Journal of Traditional and Complementary Medicine·Liang-Tzung LinChun-Ching Lin
Jul 16, 2009·Journal of Periodontal Research·Y HiroshimaJ Kido
Dec 24, 2019·American Journal of Health Promotion : AJHP·Camille A RobinsonPamela A Matson
Sep 11, 2020·The American Journal of Chinese Medicine·Shuang LiDong Shang
Jan 25, 2021·Journal of Ethnopharmacology·Zhonglei Wang, Liyan Yang
Feb 17, 2021·Phytotherapy Research : PTR·Sofi Imtiyaz AliShowkat Ul Nabi
Jun 3, 2021·Viruses·Maria Musarra-PizzoMaria Teresa Sciortino
Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian ChenYong-Bing Cao

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