Xiaoke Pill () and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions

Chinese Journal of Integrative Medicine
Chuk-Ching ChanZhi-Xiu Lin

Abstract

To critically analyze the clinically-based evidence of herb-drug interaction on Xiaoke Pill () and its concomitant use with anti-diabetic drugs. MEDLINE, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Allied and Complementary Medicine Database (AMED), International Pharmaceutical Abstracts (IPA), Chinese BioMedical Literature Database (CBM), Traditional Chinese Medical Database System (TCMDS), China National Knowledge Infrastructure Database (CNKI) and Wangfang Databases were searched. Levels of Evidence and Severity Level of Interaction were used to evaluate the quality of the included studies. A total of 27 studies published in Chinese, including 2 randomized controlled trials, 3 case series and 22 case reports, were included. Eighteen herbdrug interactions were reported involving Xiaoke Pill as monotherapy, while 6 herb-drug interactions occurred associated with Xiaoke Pill in combination with anti-diabetic drugs. The clinical results of herb-drug interaction of Xiaoke Pill were reported as additive blood glucose-lowering effects with anti-diabetic drugs, including benefifi cial and adverse hypoglycemic effects, anaphylactic shock and severe hair loss. Of these interactions 82.8%...Continue Reading

References

Feb 1, 1995·JAMA : the Journal of the American Medical Association·K F SchulzD G Altman
Dec 1, 1994·Social Science & Medicine·C L LamI J Lauder
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Dec 6, 2005·Metabolism: Clinical and Experimental·Ervin SzokeJohn E Gerich
Jul 17, 2007·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jia-qing Zhang
Nov 10, 2010·The American Journal of Chinese Medicine·Zhen SangRory J McCrimmon
Apr 6, 2012·Trends in Pharmacological Sciences·Aleksi TornioJanne T Backman
Mar 6, 2013·PloS One·Linong JiUNKNOWN Evidence-Based Medical Research of Xiaoke Pill Study Group
Aug 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ka WuRong Li

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