Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Hui-Zheng ZhuJiaxu Chen

Abstract

Depression has become the leading cause of disability worldwide and a growing public health problem in China. In addition, intestinal flora may be associated with depression. This study investigated the effect of the decoction Xiaoyaosan (XYS) against depressive behavior through the regulation of intestinal flora. Fifty-two healthy male Sprague-Dawley rats were randomly divided into four groups (i.e., control, model, XYS, and fluoxetine). The latter three groups were subjected to 21 days of chronic restraint stress to produce the stress depression model. Rats in the XYS and fluoxetine groups received intragastric administration of XYS and fluoxetine, respectively. The behavioral changes of the rats were observed after 21 days. Stool specimens were sequenced using the 16S rDNA high-throughput method to detect the structure and changes in intestinal flora. There was no difference observed in alpha diversity among the groups. At the phylum level, XYS regulated the abundance of Bacteroidetes, Proteobacteria, Firmicutes, Chloroflexi, and Planctomycetes. At the genus level, XYS reduced the abundance of the Prevotellaceae_Ga6A1_group, Prevotellaceae_UCG-001, and Desulfovibrio. On the contrary, it increased the abundance of the Ruminoc...Continue Reading

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Citations

Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lina LiuFei Qiao
May 15, 2020·Scientific Reports·Cláudia SouzaSergio C Oliveira
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
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Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel
Jun 11, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shiyun ShaoYan Wang
Jun 7, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaojie LiuXuemei Qin

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