Xiaoyaosan Improves Depressive-Like Behaviors in Mice through Regulating Apelin-APJ System in Hypothalamus

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhi-Yi YanJiaxu Chen

Abstract

Background: The apelin-APJ system has been considered to play a crucial role in HPA axis function, and how the traditional Chinese compound prescription Xiaoyaosan regulates the apelin-APJ system as a supplement to treat depressive disorders. Objective: To investigate the depression-like behaviors and expression of apelin and APJ in hypothalamus of chronic unpredictable mild stress (CUMS) mice and study whether these changes related to the regulation of Xiaoyaosan. Methods: 60 adult C57BL/6J mice were randomly divided into four groups, including control group, CUMS group, Xiaoyaosan treatment group and fluoxetine treatment group. Mice in the control group and CUMS group received 0.5 mL physiological saline once a day by intragastric administration. Mice in two treatment groups received Xiaoyaosan (0.25 g/kg/d) and fluoxetine (2.6 mg/kg/d), respectively. After 21 days of modeling with CUMS, the expression of apelin and APJ in hypothalamus were measured by real-time fluorescence quantitative PCR, western blot and immunohistochemical staining. The physical condition, body weight, food intake and behavior tests such as open field test, sucrose preference test and force swimming test were measured to evaluate depressive-like behavio...Continue Reading

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Citations

Aug 3, 2018·Journal of Cellular Physiology·Zhen HuangLinxi Chen
Mar 17, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yajing HouJiaxu Chen
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Nov 17, 2020·Frontiers in Synaptic Neuroscience·Eva Maria FritzDimitri De Bundel

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Methods Mentioned

BETA
protein assay

Software Mentioned

SPSS
Tanon Gis
Etho Vision
Imagepro Plus
GraphPad Prism

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