Xiaoyaosan Produces Antidepressant Effects in Rats via the JNK Signaling Pathway

Complementary Medicine Research
Hong-Bo ZhaoWei-Jun Gong

Abstract

Xiaoyaosan (XYS) has achieved definite curative effects in clinic. However, the mechanism is not clear. Previous studies of our team indicated XYS improved anxiety-like behaviors through inhibiting c-Jun N-terminal kinase (JNK) signaling pathway of hippocampus. In the study, we explored whether the JNK signaling pathway is involved in the mechanism of XYS treating depression. Forty-eight rats were divided randomly into 4 groups (n = 12): the control group (deionized water, p.o.), the model group (deionized water, p.o.), the fluoxetine group (2.08 mg/kg/day, p.o.), and the XYS group (3.9 g/kg/day, p.o.). All rats except for the control group were given continuous 21 days of chronic immobilization stress (CIS; 3 h/day). On day 29, the body weights and the behavioral tests, including the novelty suppressed feeding test, the open field test, and the elevated plus maze test, were measured. On day 30, all the rats were sacrificed, and three indices of the JNK signaling pathway were tested by Western blot. The body weight and behavioral tests of all groups indicated that 21 days of CIS induced depression-like behaviors. After 21 days of treatment with fluoxetine and XYS, changes were seen in body weight, behaviors, and JNK, phosphoryl...Continue Reading

References

Aug 27, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Yuqing ZhangJianping Liu
Jan 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiu-Fang DingZhi-Ping Lv
Oct 29, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Na LiJia-Xu Chen
Apr 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·You-Ming JiangJia-Xu Chen
Jan 18, 2017·Behavioural Brain Research·Wen-Jun SuChun-Lei Jiang
Jan 22, 2019·Journal of Visualized Experiments : JoVE·Zhi-Yi YanJia-Xu Chen

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