PMID: 16614732Apr 15, 2006Paper

Ximelagatran, the new oral anticoagulant: would warfarin survive the challenge?

Cardiovascular Drug Reviews
Shaker A Mousa, Hikmat N Abdel-Razeq

Abstract

The last decade witnessed major advances in the prevention and treatment of venous as well as of arterial thrombosis. Limitations of existing anticoagulants led to the development of novel therapeutic approaches. Ximelagatran is a new direct thrombin inhibitor (DTI) that is given orally, without the need for close monitoring. This compound was tried in the treatment of active venous thromboembolism, and the results were encouraging. Randomized trials suggest that ximelagatran is not inferior to warfarin in the prevention of stroke in patients with nonvalvular atrial fibrillation. Multiple controlled, prospective trials compared ximelagatran with low molecular weight heparin or warfarin in prevention of venous thromboembolism in patients undergoing major orthopedic procedures. The results of these clinical trials are reviewed in this article. Because of certain safety concerns (increased liver enzymes, potential hepatonecrosis, and increased coronary events) ximelagatran has not yet been approved by the FDA. Additional studies may be required to address these concerns. Ximelagatran has been approved, however, by the European regulatory authorities for short-term thromboprophylaxis. The success of ximelagatran or other oral antit...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Apr 25, 1994·Archives of Internal Medicine·W D KniffinF A Anderson
Jun 1, 1994·Annals of Internal Medicine·E M Hylek, D E Singer
Oct 1, 1996·The British Journal of Surgery·T E GilliesS J Nixon
Feb 7, 2001·Chest·J AnsellD Matchar
Feb 7, 2001·Chest·W H GeertsH B Wheeler
Apr 9, 2001·Clinics in Liver Disease·J H Lewis, H J Zimmerman
Jul 19, 2002·Seminars in Hematology·Karen L Kaplan, Charles W Francis
Oct 29, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Edith Nutescu, Eric Racine
Feb 14, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ulf G ErikssonDavid Gustafsson
Apr 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bernd Clement, Katrin Lopian
Sep 12, 2003·The New England Journal of Medicine·Robert G Hart
Oct 31, 2003·The New England Journal of Medicine·Charles W FrancisUNKNOWN EXULT A Study Group
Oct 31, 2003·The New England Journal of Medicine·Sam SchulmanUNKNOWN THRIVE III Investigators
Feb 6, 2004·Stroke; a Journal of Cerebral Circulation·Graeme J HankeyJohn W Eikelboom
Jun 17, 2004·Seminars in Vascular Medicine·Jeffrey Weitz
May 21, 2005·Clinical Pharmacology and Therapeutics·Marie CullbergMats O Karlsson
Aug 27, 2005·Seminars in Vascular Medicine·Michael WolztUlf G Eriksson
Dec 6, 2005·Journal of the American College of Cardiology·Sanjay KaulWilliam S Weintraub

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Citations

Dec 17, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Evi Kalodiki, Jawed Fareed

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