Xinhuang Tablets Improve Intestinal Barrier Function via Regulating Epithelial Tight Junctions in Dextran Sulfate Sodium-Induced Ulcerative Colitis Mice.

Journal of Medicinal Food
Meizhu WuJun Peng

Abstract

Intestinal mucosal barrier dysfunction is involved in the pathogenesis of inflammatory bowel disease, including ulcerative colitis (UC). Xinhuang tablets (XHTs) have been prescribed for several kinds of inflammatory diseases, including UC, whereas its possible underlying molecular mechanisms had never been explored. Mouse model of UC was constructed by DSS treatment and followed by XHT treatment. Disease activity index, histopathological of colonic tissue, tumor necrosis factor-alpha (TNF-α), and serum amyloid A (SAA) levels in serum were further assessed. The underlying mechanism was further explored by determination of the expression of epithelial tight junction-related protein. XHT administration ameliorated dextran sulfate sodium (DSS)-induced clinical symptoms, colonic histological injury, and decreased the circulating levels of TNF-α and SAA. Moreover, XHT treatment significantly increased the protein levels of zona occludens (ZO)-1, whereas decreased the levels of phosphorylation of Elk-1. In conclusion, this study confirmed the therapeutic effects of XHT treatment on UC in a DSS-induced mouse model, and indicated that by increasing expression of epithelial tight junctions and decreasing phosphorylation of Elk-1 might be...Continue Reading

References

Nov 1, 1990·The New England Journal of Medicine·A EkbomH O Adami
Jan 6, 2001·Scandinavian Journal of Gastroenterology·I D ArnottS Ghosh
Feb 10, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas Y MaHamid M Said
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·J Eaden
Oct 29, 2005·Inflammatory Bowel Diseases·Kim L IsaacsStephan R Targan
Dec 27, 2005·Inflammatory Bowel Diseases·Stephen B Hanauer
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·C CanavanJ Mayberry
Oct 16, 2007·The Journal of Investigative Dermatology·Carien M Niessen
Nov 28, 2007·The Journal of Experimental Medicine·Mike G LaukoetterCharles A Parkos
Apr 16, 2008·Expert Opinion on Therapeutic Targets·Arthur Kaser, Herbert Tilg
Jul 28, 2009·Current Opinion in Pharmacology·Karen L Edelblum, Jerrold R Turner
Oct 27, 2009·Nature Reviews. Immunology·Jerrold R Turner
Apr 22, 2010·Journal of Cellular and Molecular Medicine·Rana Al-SadiThomas Y Ma
Jun 17, 2011·Nature·Kevin J Maloy, Fiona Powrie
Jul 13, 2011·Digestive Diseases and Sciences·Lisa S PoritzWalter A Koltun
Oct 15, 2013·The American Journal of Pathology·Rana Al-SadiThomas Y Ma
Jan 15, 2014·World Journal of Gastroenterology : WJG·Yi-Zhen Zhang, Yong-Yu Li
Mar 3, 2015·Therapeutic Advances in Gastroenterology·Aurelien Amiot, Laurent Peyrin-Biroulet
Mar 10, 2015·Gastroenterology·Brian BresslerUNKNOWN Toronto Ulcerative Colitis Consensus Group
Jan 1, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yi GongYan Li
Apr 23, 2016·Inflammatory Bowel Diseases·Andreas R JaneckeThomas Müller

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
blood collection
protein assay

Software Mentioned

SPSS
ImageLab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.