Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification

The EMBO Journal
E J BellefroidN Papalopulu

Abstract

We have identified in Xenopus and in the mouse two highly related genes, Xiro3 and Irx3 respectively, that encode a Drosophila Iroquois-related homeobox transcription factor. Xiro3 in Xenopus and Irx3 in the mouse are expressed early in the prospective neural plate in a subset of neural precursor cells. In Xenopus, injection of Xiro3 mRNA expands the neural tube and induces ectopic neural tissue in the epidermis, based on the ectopic expression of early neural markers such as Xsox3. In contrast, the differentiation of the early forming primary neurons, as revealed by the expression of the neuronal marker N-tubulin, is prevented by Xiro3 expression. Activation of Xiro3 expression itself requires the combination of a neural inducing (noggin) and a posteriorizing signal (basic fibroblast growth factor). These results suggest that Xiro3 activation constitutes one of the earliest steps in the development of the neural plate and that it functions in the specification of a neural precursor state.

References

Jun 1, 1992·Trends in Genetics : TIG·S Campuzano, J Modolell
Apr 1, 1991·Neuron·W A Harris, V Hartenstein
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E JonasI B Dawid
Jun 29, 1995·Nature·P Simpson
Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Dec 1, 1994·Developmental Biology·M A Muskavitch
Oct 29, 1993·Science·T M LambR M Harland
Aug 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A K SaterR Keller
May 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Ghysen, C Dambly-Chaudière
Mar 7, 1996·Nature·P H CrossleyG R Martin
Feb 1, 1996·Current Opinion in Neurobiology·J Lewis
Dec 1, 1995·Neuron·L SommerD J Anderson
Feb 1, 1997·Current Biology : CB·N E Baker, S Y Yu
Jul 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M RexP J Scotting

❮ Previous
Next ❯

Citations

May 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Vervoort
Jul 9, 2002·Current Opinion in Genetics & Development·José Luis Gómez-Skarmeta, Juan Modolell
Feb 21, 2003·Current Opinion in Neurobiology·Laure Bally-Cuif, Matthias Hammerschmidt
Oct 6, 1999·Current Opinion in Neurobiology·Y M Chan, Y N Jan
Mar 11, 1999·Current Opinion in Neurobiology·A B Chitnis
Aug 28, 2012·The Journal of Biological Chemistry·Douglas M AndersonAlan Rawls
May 13, 2008·Molecular Biology and Evolution·Manuel IrimiaJordi Garcia-Fernàndez
Sep 19, 2007·Genes & Development·Luca ReggianiAndré W Brändli
Jul 19, 2005·Genome Research·Elisa de la Calle-MustienesJosé Luis Gómez-Skarmeta
Mar 10, 2001·Molecular and Cellular Biology·B G BruneauJ G Seidman
Dec 28, 1999·Annual Review of Cell and Developmental Biology·D C Weinstein, A Hemmati-Brivanlou
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A SethC P Vary
Jul 13, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sarah E KerrSarah M Dry
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aphrodite BilioniHelen McNeill
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M PerronE J Bellefroid
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Kudoh, I B Dawid
Sep 23, 2014·Molecules and Cells·Hyun-Kyung LeeSally A Moody
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J J BainterK L Kroll
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katharine E LewisJudith S Eisen
Dec 30, 2008·Molecular and Cellular Neurosciences·Carmen Gloria FeijóoMiguel L Allende
Sep 15, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Crystal D RogersElena S Casey
Mar 3, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bo YanSally A Moody
Dec 20, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jean C IllesHarry V Isaacs
May 4, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emily F WinterbottomHarry V Isaacs
Jan 13, 2006·Experimental Cell Research·Xuelin LiXu Cao
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·Gerhard Schlosser
Jul 14, 2012·Developmental Biology·Timothy GrocottAndrea Streit
Dec 15, 2010·Developmental Biology·Tenley C ArcherElena S Casey
Feb 7, 2012·Developmental Biology·Cécile Milet, Anne H Monsoro-Burq
Dec 11, 2013·Developmental Biology·Andrew K Groves, Carole LaBonne
Dec 4, 2001·Mechanisms of Development·V LecaudeyS Schneider-Maunoury
Sep 24, 1999·Mechanisms of Development·A GorielyK G Storey
Apr 9, 2005·Mechanisms of Development·Weeteck Yeo, Jean Gautier
Mar 8, 2000·Mechanisms of Development·D R CohenC C Hui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.