PMID: 9169581Jun 1, 1997Paper

Xist RNA is associated with the transcriptionally inactive XY body in mammalian male meiosis

Chromosoma
N AyoubJ Wahrman

Abstract

In eutherian mammals, X inactive-specific transcripts (Xist) are expressed in somatic cells possessing more than one X chromosome, and in germline cells of males, in which the single X chromosome is transcriptionally inactive. In early meiosis of males the sex chromosomes form an inactive XY nuclear compartment (XY body). We show by in situ reverse-transcribed polymerase chain reaction that Xist RNA is concentrated in the XY body. This fine localization suggests that Xist RNA is involved in inactivation of the male X chromosome, and that it has spreading capability, not only in cis but also in a quasi-cis mode, to juxtaposed non-X chromosomes. A hypothetical scheme links the evolution of heteromorphic sex chromosomes to the development of X condensation/inactivation in the male. The mechanism of X inactivation in somatic cells of mammalian females, resulting in male/female dosage compensation, has been recruited from the Xist-activated chromosome condensation machinery that developed in male meiosis earlier in evolution.

Citations

Sep 11, 2001·The Journal of Experimental Zoology·A FarazmandP K Basrur
Jan 5, 2002·Molecular Reproduction and Development·Maurizio ZuccottiCarlo Alberto Redi
Jan 8, 2011·World Journal of Surgery·Sarah M WeakleyChangyi Chen
Mar 24, 2004·Trends in Endocrinology and Metabolism : TEM·P Jeremy Wang
Apr 25, 2003·Trends in Genetics : TIG·Chung I Wu, Eugene Yujun Xu
Oct 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Paul FranszIngo Schubert
Apr 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shridar GanesanDavid M Livingston
Aug 20, 2004·European Journal of Biochemistry·Jérôme GovinSaadi Khochbin
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·John D LewisJuan Ausió
Aug 30, 2008·Annual Review of Genetics·Bernhard Payer, Jeannie T Lee
Nov 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilDaniel J Driscoll
Mar 18, 2006·Chromosoma·Jesús PageJulio S Rufas
Aug 5, 1998·Current Opinion in Genetics & Development·N Brockdorff
Nov 16, 2002·Genesis : the Journal of Genetics and Development·John R McCarreyStephen A Krawetz
Oct 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sha SunJeannie T Lee
Nov 8, 2007·Genesis : the Journal of Genetics and Development·Jacey L HorneckerJohn R McCarrey
Nov 25, 2011·Molecular Reproduction and Development·Paula M Checchi, Joanne Engebrecht
Jun 18, 2015·Molecular and Cellular Therapies·Roshan FatimaSatyanarayana Mr Rao
Nov 14, 2002·Annual Review of Genetics·Kathrin PlathBarbara Panning
Jul 18, 2000·Experimental Cell Research·S Hoyer-FenderJ R Pehrson
Apr 12, 2003·Developmental Cell·Oscar Fernandez-CapetilloAndré Nussenzweig
Nov 7, 2002·Cell·Shridar GanesanDavid M Livingston
Aug 27, 1998·American Journal of Human Genetics·A E Ashley-KochS L Sherman
May 22, 2010·Clinical Pediatrics·Gabriele Bronzetti, Alessandro Corzani
Feb 28, 2018·High-throughput·Shizuka Uchida
Nov 10, 2018·Annual Review of Animal Biosciences·Wan-Sheng Liu
Jun 12, 2010·Genetika·E A Vas'kovaS M Zakinian
Dec 13, 2005·Critical Reviews in Biochemistry and Molecular Biology·Pavel P Khil, R Daniel Camerini-Otero
Oct 3, 2002·Journal of Cell Science·James M A TurnerPaul S Burgoyne
Mar 3, 2007·Development·James M A Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.