Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos

Oncogene
Ryu MaedaI O Daar

Abstract

Meis1 (Myeloid Ecotropic viral Integration Site 1) is a homeobox gene that was originally isolated as a common site of viral integration in myeloid tumors of the BXH-2 recombinant inbred mice strain. We previously isolated a Xenopus homolog of Meis1 (Xmeis1). Here we show that Xmeis1 may play a significant role in neural crest development. In developing Xenopus embryos, Xmeis1 displays a broad expression pattern, but strong expression is observed in tissue of neural cell fate, such as midbrain, hindbrain, the dorsal portion of the neural tube, and neural crest derived branchial arches. In animal cap explants, overexpression of Xmeis1b, an alternatively spliced form of Xmeis1, induces expression of neural crest marker genes in the absence of mesoderm. Moreover, Xmeis1b induces XGli-3 and XZic3, pre-pattern genes involved at the earliest stages of neural crest development, and like these two genes, can induce ectopic pigmented cell masses when overexpressed in developing embryos. Misexpression of Xmeis1b also induces ectopic expression of neural crest markers along the antero-posterior axis of the neural tube in developing Xenopus embryos. In contrast, Xmeis1a, another splice variant, is much less effective at inducing these effe...Continue Reading

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S J HarlandA Horwich
Jan 1, 1991·Methods in Cell Biology·R M Harland
Aug 1, 1991·British Journal of Urology·N W ClarkeN J George
Jul 11, 1991·Nucleic Acids Research·R S WinningT D Sargent
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A PerkinsS Cory
Nov 1, 1986·The Journal of Cell Biology·S MiyataniI B Dawid
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RichterI B Dawid
Dec 1, 1966·Experimental and Molecular Pathology·H D Mayor, L E Jordan
Oct 1, 1995·Molecular and Cellular Biology·J J MoskowA M Buchberg
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S T NeuteboomC Murre
Aug 1, 1995·Molecular and Cellular Biology·M L PhelanM S Featherstone
Apr 22, 1994·Cell·A Hemmati-Brivanlou, D A Melton
Dec 1, 1993·British Journal of Urology·P A Anderson, A H Travers
Apr 20, 1996·British Dental Journal·A Richardson
Aug 1, 1996·Developmental Biology·A Mancilla, R Mayor
Feb 1, 1997·Genome Research·S SteelmanA M Buchberg
Feb 1, 1997·Developmental Biology·Y Sasai, E M De Robertis
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·K NakataK Mikoshiba
Oct 29, 1997·Molecular and Cellular Biology·W F ShenC Largman
Nov 22, 1997·Current Biology : CB·J B WallingfordP D Vize
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·J P Saint-JeannetI B Dawid
Jan 27, 1998·Hematology/oncology Clinics of North America·U ThorsteinsdottirR K Humphries
Apr 18, 1998·The EMBO Journal·J BerthelsenF Blasi
Mar 5, 1998·Nature·A Ruiz i Altaba
Mar 11, 1998·The Australian and New Zealand Journal of Surgery·B CarnailleC Proye
May 16, 1998·Nature·F Casares, R S Mann

❮ Previous
Next ❯

Citations

Feb 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Keiko AkagiIra O Daar
May 16, 2009·Journal of Neurology·Claudia TrenkwalderJuliane Winkelmann
Aug 6, 2008·MMW Fortschritte der Medizin·J Zeitlhofer
May 28, 2005·Cancer Letters·Dirk GeertsRogier Versteeg
Jul 26, 2003·Cancer Letters·Dirk GeertsRogier Versteeg
Jul 9, 2002·Current Opinion in Genetics & Development·Manuel J Aybar, Roberto Mayor
Jan 27, 2004·Molecular Biology of the Cell·Eui Kyun ParkIra O Daar
Jun 18, 2011·Genome Biology and Evolution·Manuel IrimiaJosé Luis Ferran
Mar 7, 2014·PloS One·Takehiro HirayamaRyo Goitsuka
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ryu MaedaIra O Daar
Jul 12, 2014·PloS One·Kazuhiro OkumuraYuichi Wakabayashi
Jun 13, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Benjamin A BarberMojgan Rastegar
Feb 19, 2009·Journal of Psychiatric Research·B G SchimmelmannJ Hebebrand
May 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edmond Changkyun ParkJin-Kwan Han
Mar 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christa S Merzdorf
Jun 7, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gerhard Schlosser
Dec 2, 2010·The Journal of Comparative Neurology·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Apr 6, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Aug 14, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dorothea Schulte, Dale Frank
Jun 23, 2004·Molecular and Cellular Neurosciences·Jun Aruga
Nov 26, 2015·The Psychiatric Clinics of North America·Philip R GehrmanAllan I Pack
Jul 26, 2005·Seminars in Cell & Developmental Biology·Meyer Barembaum, Marianne Bronner-Fraser
Sep 4, 2015·Sleep Medicine Clinics·David B Rye
Jul 31, 2013·Current Opinion in Neurobiology·Amanda A H Freeman, David B Rye
Oct 7, 2004·Developmental Biology·Xiao Huang, Jean-Pierre Saint-Jeannet
Oct 7, 2004·Developmental Biology·Young-Hoon LeeJean-Pierre Saint-Jeannet
Oct 3, 2003·Nature Reviews. Neuroscience·Laura S Gammill, Marianne Bronner-Fraser
Jun 25, 2017·Disease Models & Mechanisms·Aaro V SalminenJuliane Winkelmann
Jun 4, 2002·Nature Reviews. Genetics·Anne K Knecht, Marianne Bronner-Fraser
Aug 17, 2019·Development·Dorothea Schulte, Dirk Geerts
Jan 18, 2005·The Journal of Biological Chemistry·He HuangMark Featherstone
Dec 7, 2018·Cellular and Molecular Life Sciences : CMLS·Dale Frank, Dalit Sela-Donenfeld
Jun 11, 2008·Current Neurology and Neuroscience Reports·Juliane Winkelmann
Oct 10, 2018·Scientific Reports·Yuri S OdakaJun Aruga
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthias FischerFrank Berthold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.