XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development

Developmental Biology
K F TonissenP A Krieg

Abstract

We have isolated a Xenopus homeodomain sequence, XNkx-2.5, which shows significant similarity to mouse Nkx-2.5 and to the Drosophila tinman gene product. In Drosophila, tinman is required for formation of the heart and visceral mesoderm structures. In situ hybridization studies show that XNkx-2.5 is expressed in the heart region during early Xenopus development and later is also expressed in gut tissue. The observed similarity of sequences and expression patterns suggests that the regulatory mechanisms underlying heart formation may be conserved between distant species.

Citations

Jun 11, 1998·Developmental Genetics·C S Newman, P A Krieg
Jan 1, 1995·Trends in Cardiovascular Medicine·R Bodmer
Mar 1, 1995·Trends in Cardiovascular Medicine·M J KernS S Potter
May 1, 1994·Trends in Cardiovascular Medicine·T MohunM Logan
Jun 1, 2005·Pharmacology & Therapeutics·Hiroshi Akazawa, Issei Komuro
Nov 1, 2002·Biochemical and Biophysical Research Communications·Koshiro MonzenIssei Komuro
Jun 29, 2001·Trends in Cardiovascular Medicine·C J HatcherC T Basson
Aug 19, 2003·Trends in Cardiovascular Medicine·Timothy MohunCatherine Shang
Oct 1, 1996·Trends in Cardiovascular Medicine·N Nascone, M Mercola
Apr 1, 1997·Trends in Cardiovascular Medicine·T Evans
Apr 30, 2008·Cardiovascular Research·Mehregan Movassagh, Anna Philpott
Jul 1, 2009·Cardiovascular Research·Robert DavidWolfgang-Michael Franz
Oct 6, 1997·The EMBO Journal·D DurocherM Nemer
Feb 3, 1997·The EMBO Journal·K GajewskiR A Schulz
Feb 3, 2005·Genes & Development·Ann C Foley, Mark Mercola
Feb 13, 2001·Genes & Development·V A Schneider, M Mercola
Oct 5, 2010·Development, Growth & Differentiation·Masahiro YamagishiMakoto Asashima
Feb 5, 2008·The Journal of Clinical Investigation·Nicolas ChristoforouJohn D Gearhart
Sep 20, 2012·BMC Developmental Biology·Emily T ShifleyAaron M Zorn
Jul 30, 2008·BMC Developmental Biology·Kim E HaworthBranko V Latinkic
Oct 12, 2007·Development·Yvette G LangdonFrank L Conlon
Jan 7, 2005·Development·Daniel D BrownFrank L Conlon
May 27, 2006·Development·Sarah C GoetzFrank L Conlon
Aug 11, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Xi-Ren GaoHai-Jie Wang
Nov 10, 2005·The Japanese Journal of Physiology·Ichiro Shiojima, Issei Komuro
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C HaunP G Okkema
May 12, 2001·Japanese Circulation Journal·I Komuro
Aug 1, 1996·Current Opinion in Genetics & Development·G E Lyons
Jul 2, 2010·Human Cell·Akira KurisakiMakoto Asashima
Mar 21, 2001·Evolution & Development·D M SmithN M Nascone-Yoder
May 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Makoto AsashimaTakashi Ariizumi
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chi ZhangMichael W Klymkowsky
Jul 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Damien ParlierEric J Bellefroid
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Heather L BartlettDaniel L Weeks
May 19, 2006·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·C HyunJ-T Kim
Jun 16, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tomomi HaremakiDaniel C Weinstein
Feb 10, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Boni A Afouda, Stefan Hoppler
Apr 21, 2010·Journal of Anatomy·Jennifer MartinStefan Hoppler
Dec 13, 2005·Seminars in Cell & Developmental Biology·Ira L BlitzMarko E Horb
Dec 4, 2003·Differentiation; Research in Biological Diversity·Robert J Garriock, Thomas A Drysdale
Apr 1, 1995·Differentiation; Research in Biological Diversity·W G Cox, A W Neff
Jul 12, 2005·Biochemical and Biophysical Research Communications·Stéphane Zaffran, Manfred Frasch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.