PMID: 738732Dec 29, 1978Paper

XO/XY mosaicism and non-fluorescing Y chromosome in a male

Human Genetics
B W Richards, A Stewart


An adult male of short stature and with underdeveloped external genitalia is described, who carried out a number of sexual assaults on young women. He proved to have XO/XY mosaicism and a non-fluorescing Y chromosome. It was considered to be a terminal deletion on morphological grounds. It is suggested, on the evidence of the small number of XO/XY mosaics examined by appropriate staining methods, that an abnormal Y chromosome, whether terminally deleted or non-fluorescing owing to an altered chemical state, predisposes to anaphase lagging and non-disjunction. Of eleven reported cases of XO/XY mosaicism with a non-fluorescing Y chromosome, this is the fifth of male phenotype. The severe behaviour disturbance of early onset is considered to be probably causally associated with the chromosome anomaly.


May 10, 1977·Human Genetics·F GiraudM G Mattei
Aug 1, 1977·Journal of Medical Genetics·E YunisM A Nossa
Jan 1, 1969·British Medical Bulletin·P A Jacobs
Dec 15, 1967·American Journal of Obstetrics and Gynecology·M N Starkman, R B Jaffe
Mar 1, 1965·American Journal of Clinical Pathology·M T LO, S D KOBERNICK

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