Xp11.2 Translocation renal cell carcinomas have a poorer prognosis than non-Xp11.2 translocation carcinomas in children and young adults: a meta-analysis

International Journal of Surgical Pathology
Qiu RaoXiao-jun Zhou

Abstract

Renal cell carcinomas (RCCs) in children and adolescents are much rarer than in adults. In this age group, Xp11.2 translocation RCCs were the most common subtype of pediatric RCCs. Information regarding the clinical behavior of pediatric RCCs remains controversial because of their relatively rare incidence. The authors aimed to perform a systematic review and meta-analysis to better define the biological features of pediatric RCCs. Eligible studies were identified through multiple search strategies. Studies were assessed for quality using the Jadad Quality Scale. Data were collected comparing overall survival (OS), disease-free survival (DFS), and stage in patients with TFE3 + pediatric RCCs and TFE3 - RCCs. A total of 4 studies were included for meta-analysis, and pooled odds ratios (ORs) with 95% confidence interval (CI) were calculated. The meta-analysis outcomes showed that TFE3 + pediatric RCCs were significantly associated with poorer outcomes (OS and DFS) and a higher stage (III/IV) than TFE3 - RCCs (pooled ORs for each group: 4.59 [95% CI = 1.46-14.42] for OS; 5.79 [95% CI = 1.85-18.16] for DFS; and 5.89 [95% CI = 2.23-15.52] for stage). This result was also confirmed by OS and DFS curves (P = .005 and P = .001). Xp11.2...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 16, 2003·Advances in Anatomic Pathology·Pedram Argani, Marc Ladanyi
Jan 31, 2006·European Urology·Antonio Lopez-BeltranZiya Kirkali
Aug 2, 2006·American Journal of Clinical Pathology·Pedram Argani, Marc Ladanyi
Jan 22, 2008·International Journal of Surgical Pathology·Ni Wayan WinartiKetut Mulyadi
Mar 21, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Takuya KoieChikara Ohyama
Apr 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·G MartignoniM Chilosi
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·John R Srigley, Brett Delahunt

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Citations

Apr 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Bellmunt, J Dutcher
Jul 2, 2015·BMC Urology·Linfeng XuHongqian Guo
Aug 27, 2013·International Journal of Surgical Pathology·Shaoyan XiJing Zeng
Feb 6, 2018·Molecular and Clinical Oncology·Xiang PanYongqing Lai
May 20, 2021·Advances in Anatomic Pathology·Nicholas BaniakMichelle S Hirsch
Jul 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Bellmunt, J Dutcher

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