XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy.

Journal of Cancer Research and Clinical Oncology
Ruchika GangwarRama D Mittal

Abstract

To investigate the association between two Xeroderma pigmentosum group C polymorphism (XPC Lys939Gln and insertion/deletion PAT -/+ in intron 9) and bladder cancer (BC) susceptibility. Genotyping was performed in 208 BC patients and 245 controls by PCR-RFLP method. XPC PAT +/+ genotype was associated with elevated risk of BC (p = 0.021, OR = 2.49). XPC Lys939Gln AC + CC genotype was significantly associated with risk in invasive stage of BC (p = 0.041, OR = 2.52). Haplotype analysis revealed that variant genotypes C of XPC Lys939Gln and + of PAT, C+ were significantly associated with risk of BC (p = 0.004, OR = 1.70). The CC genotype of Lys939Gln was associated with high risk for recurrence in BCG-treated patients (HR = 3.21, p = 0.036) thus, showing reduced recurrence-free survival (AC + CC/AA = 36/60 months; log rank p = 0.045). Polymorphisms and haplotypes in XPC appear to influence susceptibility to BC risk. The variant C allele at Lys939Gln may be responsible for early recurrence in BCG-treated patients.

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Citations

Oct 6, 2010·Future Oncology·Anne J GrotenhuisLambertus A Kiemeney
Aug 29, 2012·International Journal of Medical Sciences·Yi ZhiJin Yang
Aug 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiang-Sheng DaiZhen-Wei Peng
Dec 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhangShengkai Gong
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Jing HeQing-Yi Wei
Feb 18, 2018·Irish Journal of Medical Science·Cavit CeylanGulay Ceylan
Jun 21, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Saima Shakil MalikRazia Bano
Jan 8, 2020·Biomarkers in Cancer·Nadezda LipunovaMaurice P Zeegers

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