Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance.

The Cochrane Database of Systematic Reviews
Mikashmi KohliKaren R Steingart

Abstract

Tuberculosis (TB) is the world's leading infectious cause of death. Extrapulmonary TB accounts for 15% of TB cases, but the proportion is increasing, and over half a million people were newly diagnosed with rifampicin-resistant TB in 2016. Xpert® MTB/RIF (Xpert) is a World Health Organization (WHO)-recommended, rapid, automated, nucleic acid amplification assay that is used widely for simultaneous detection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum specimens. This Cochrane Review assessed the accuracy of Xpert in extrapulmonary specimens. To determine the diagnostic accuracy of Xpert a) for extrapulmonary TB by site of disease in people presumed to have extrapulmonary TB; and b) for rifampicin resistance in people presumed to have extrapulmonary TB. We searched the Cochrane Infectious Diseases Group Specialized Register, MEDLINE, Embase, Science Citation Index, Web of Science, Latin American Caribbean Health Sciences Literature (LILACS), Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number (ISRCTN) Registry, and ProQuest up to 7 August 2017 without language restriction. We included diagnostic accuracy st...Continue Reading

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Methods Mentioned

BETA
biopsy
nucleic acid amplification
PCR
lavage

Software Mentioned

Stata
Covidence
GRADE
GRADEpro Guideline Development Tool ( GDT )
OpenBUGS
GeneXpert
Scopus
Review Manager
BIOSIS Previews
QUADAS

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