Xpert MTB/RIF assay for the diagnosis of rifampicin resistance in different regions: a meta-analysis

BMC Microbiology
Kaican ZongShiying Li

Abstract

To estimate the diagnostic accuracy of Xpert MTB/RIF for rifampicin resistance in different regions, a meta-analysis was carried out. Several databases were searched for relevant studies up to March 3, 2019. A bivariate random-effects model was used to estimate the diagnostic accuracy. We identified 97 studies involving 26,037 samples for the diagnosis of rifampicin resistance. The pooled sensitivity, specificity and AUC of Xpert MTB/RIF for rifampicin resistance detection were 0.93 (95% CI 0.90-0.95), 0.98 (95% CI 0.96-0.98) and 0.99 (95% CI 0.97-0.99), respectively. For different regions, the pooled sensitivity were 0.94(95% CI 0.89-0.97) and 0.92 (95% CI 0.88-0.94), the pooled specificity were 0.98 (95% CI 0.94-1.00) and 0.98 (95% CI 0.96-0.99), and the AUC were 0.99 (95% CI 0.98-1.00) and 0.99 (95% CI 0.97-0.99) in high and middle/low income countries, respectively. The pooled sensitivity were 0.91 (95% CI 0.87-0.94) and 0.91 (95% CI 0.86-0.94), the pooled specificity were 0.98 (95% CI 0.96-0.99) and 0.98 (95% CI 0.96-0.99), and the AUC were 0.98 (95% CI 0.97-0.99) and 0.99 (95% CI 0.97-0.99) in high TB burden and middle/low prevalence countries, respectively. The diagnostic accuracy of Xpert MTB/RIF for rifampicin resistan...Continue Reading

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Citations

Feb 6, 2021·Wellcome Open Research·Fiona V CresswellUNKNOWN Tuberculous Meningitis International Research Consortium
Mar 9, 2021·Journal of Clinical Orthopaedics and Trauma·Vijay KarthekSiddharth N Aiyer

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Methods Mentioned

BETA
nucleic acid amplification
biopsy
lavage

Software Mentioned

QUADAS
STATA
Review Manager

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