Abstract
Cerebral ischemic and reperfusion injury often accompany with inflammation, and lead to severe neuronal damage, which further result in neurological disorders and memory disorders. In this study, we researched XQ-1H, a novel derivative of ginkgolide B, protecting against ischemic stroke in mice through regulation of microglia polarization. Middle cerebral artery occlusion (MCAO)/reperfusion in mice is applied to mimic ischemic stroke in vivo. Immediately after MCAO, mice are intragastric administrated with different dose (31 or 62 mg/kg) of XQ-1H for one or continuative three days. The in vivo experiments indicated that post-treatment with XQ-1H decreased cerebral infarction size, lessened brain edema, improved behavior and memory recover, inhibited pro-inflammatory and promoted anti-inflammatory cytokines expression and releasing in MCAO mice. Oxygen-glucose deprivation/reoxygenation (OGD/R) injury in BV-2 (microglia) cells is served in vitro. The in vitro findings revealed that incubation with XQ-1H protected against BV2 from OGD/R injury, regulated BV2 polarized from pro-inflammatory into anti-inflammatory phenotype, and promoted PPARγ mobilizing from nuclear to cytoplasm. In conclusion, the present study demonstrates that X...Continue Reading
Citations
Nov 16, 2019·BMC Neurology·Zhenzhen ZhaoTao Xu
Apr 24, 2020·Molecular Medicine Reports·Cheng-Ting JiangJin-Wen Ge
Aug 8, 2020·Cell Biology International·Dan XuYunman Li
Feb 20, 2019·Frontiers in Cellular Neuroscience·Jun WuLan-Jun Li
Sep 19, 2020·Clinical Proteomics·Zili FengJia Cheng
Nov 1, 2020·Translational Stroke Research·Junxuan LyuJun Chen
Jan 12, 2021·International Immunopharmacology·Lin LiLisheng Chu
Dec 8, 2020·Frontiers in Neurology·Yanping DingBaoping Shao
Feb 17, 2021·Human & Experimental Toxicology·Li YaoZhengguo Qiu
Feb 20, 2021·Life Sciences·Yuxiang FeiYunman Li
Mar 11, 2021·Journal of Immunology Research·Dong HanYan Gao
Jun 12, 2020·Journal of Ethnopharmacology·Ge LiuWeirong Fang
Jul 18, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bayarmaa KhadankhuuYunman Li
Apr 6, 2021·Aging and Disease·Yimeng XueJizong Zhao
Sep 12, 2020·Brain Research Bulletin·Yu-Xiang FeiYun-Man Li