PMID: 8948628Nov 15, 1996Paper

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

Nucleic Acids Research
K W CaldecottS Shall

Abstract

The DNA repair proteins XRCC1 and DNA ligase III are physically associated in human cells and directly interact in vitro and in vivo. Here, we demonstrate that XRCC1 is additionally associated with DNA polymerase-beta in human cells and that these polypeptides also directly interact. We also present data suggesting that poly (ADP-ribose) polymerase can interact with XRCC1. Finally, we demonstrate that DNA ligase III shares with poly (ADP-ribose) polymerase the novel function of a molecular DNA nick-sensor, and that the DNA ligase can inhibit activity of the latter polypeptide in vitro. Taken together, these data suggest that the activity of the four polypeptides described above may be co-ordinated in human cells within a single multiprotein complex.

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Citations

May 8, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K W Caldecott
Aug 9, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L DianovD T Goodhead
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A E Tomkinson, D S Levin
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Roberta PastorelliLuisa Airoldi
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Deyin XingDongxin Lin
Apr 17, 2001·International Journal of Cancer. Journal International Du Cancer·G MatulloP Vineis
Apr 1, 2005·Pathology Oncology Research : POR·Semra DemokanNejat Dalay
Sep 17, 2010·Cellular and Molecular Life Sciences : CMLS·Samuel H WilsonMichelle L Heacock
Nov 17, 2009·International Journal of Colorectal Disease·Zheng JiangSanjun Cai
Dec 11, 2008·Biochemical Genetics·Chao WangSongbin Fu
Oct 26, 2006·Breast Cancer Research and Treatment·Pia SillanpääAri Hirvonen
Feb 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Aga Syed Sameer
May 26, 2005·Cancer Letters·Chih-Ching YehFung-Chang Sung
May 18, 2005·Cancer Detection and Prevention·Tianli Qu, Kanehisa Morimoto
Nov 26, 2003·Mutation Research·Grigory L DianovSarah L Allinson
Mar 6, 2003·Mechanisms of Ageing and Development·Warren LadigesAlasdair MacAuley
Sep 29, 2000·Pharmacology & Therapeutics·A G McLennan
Nov 6, 2003·Toxicology·Markus ChristmannBernd Kaina
Jun 1, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Lynn Harrison, Svitlana Malyarchuk
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B L Weber, K L Nathanson
Feb 28, 2003·Ageing Research Reviews·Marie-Laure Muiras
Feb 28, 2003·DNA Repair·Yoshiko Kubota, Saburo Horiuchi
May 28, 2003·DNA Repair·John Thacker, Małgorzata Z Zdzienicka
Sep 12, 2003·DNA Repair·Keith W Caldecott
Jul 16, 2008·Nature Reviews. Genetics·Keith W Caldecott
Jun 21, 2012·Nature Reviews. Molecular Cell Biology·Bryan A Gibson, W Lee Kraus

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