Xtn3 is a developmentally expressed cardiac and skeletal muscle-specific novex-3 titin isoform.

Gene Expression Patterns : GEP
Daniel D BrownFrank L Conlon

Abstract

Titin proteins play an essential role in maintaining muscle function and structure. Recent work has implicated the involvement of the novex-3 titin isoform in sarcomere restructuring and disease. Unlike avian and mammalian systems, Xenopus laevis myogenesis is characterized by a wave of primary myogenesis followed by apoptosis of the primary muscles and formation of new muscles by secondary myogenesis. We show here that the Xenopus laevis novex-3 titin isoform (Xtn3) is developmentally expressed throughout the somites, heart, and primary muscles of the developing embryo. Downregulation of Xtn3 expression at tadpole stages appears to coincide with the change in myofiber composition from solely embryonic "fast" fiber types to myofibers containing both "fast" and "slow" fiber types. We demonstrate that Xtn3 is expressed early in the presomitic mesoderm and remains expressed in the somites, ventral myoblasts, and developing jaw muscles through late tailbud stage. Furthermore, we show that Xtn3 is expressed in the cardiac primordia prior to linear heart tube formation and remains expressed in the heart until tadpole stage, at which point it is downregulated in the heart except in discrete patches of cardiac cells. Finally, we demons...Continue Reading

References

Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christophe Chanoine, Serge Hardy

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Citations

Nov 8, 2007·Genesis : the Journal of Genetics and Development·Daniel D BrownFrank L Conlon
May 17, 2017·Biophysics Reviews·Dalma KellermayerHenk Granzier
Aug 19, 2018·Scientific Reports·Ken HashimotoSatoshi Mohri

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