Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Frontiers in Pharmacology
Tiantian LiYuejuan Zheng

Abstract

A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty of treatment in septic patients. Host-directed therapy (HDT) is an emerging approach to bacterial infections. Xuebijing injection (XBJ), a commercialized injectable prescription from traditional Chinese medicine, has been used as adjuvant therapy for sepsis with a history of 15 years. Whether it plays a protective role in severe infection caused by antibiotic-resistant bacteria is still unknown. In this study, XBJ significantly improved the survival of MRSA-induced sepsis mice. In MRSA-infected mouse model, XBJ down-regulated the expression of inflammatory cytokines interleukin (IL)-6, tumor necrosis factor (TNF)-α, MCP-1, MIP-2, and IL-10 in sera. Besides that, it decreased the bacterial load in spleens, livers, and alleviated tissue damage of lung, liver, and kidney. The combination of XBJ with vancomycin or dexamethasone exhibited a better down-regulatory role of the inflammatory response. Then, the protective mechanism of XBJ was further investigated. XBJ inhibited heat-killed MRSA-induced IL-6 and TNF-α production i...Continue Reading

References

Jul 18, 2002·Intensive Care Medicine·P M LepperM Trautmann
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Fernando A BozzaPatrícia T Bozza
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Mar 20, 2008·Nature Immunology·Xuetao Cao
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Oct 22, 2010·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·R KöckA W Friedrich
Apr 19, 2011·Phytochemical Analysis : PCA·Hao HuangGuoan Luo
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Mar 13, 2014·Trends in Microbiology·Huizhi WangDavid A Scott
Apr 30, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Qin Yin, Chunsheng Li
Oct 1, 2014·JAMA : the Journal of the American Medical Association·Thomas L HollandVance G Fowler
Jan 30, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Courtney A GidengilGrace M Lee
Jun 17, 2015·Scientific Reports·Maja SurbatovicSonja Radakovic
Dec 4, 2015·The Cochrane Database of Systematic Reviews·Djillali AnnaneYizhak Kupfer
Apr 3, 2016·The Lancet Infectious Diseases·Alimuddin ZumlaUNKNOWN Host-Directed Therapies Network consortium
Apr 17, 2016·The Journal of Surgical Research·Liang WangXiaochun Ma
May 25, 2016·BMJ : British Medical Journal·Jeffrey E Gotts, Michael A Matthay
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Mar 2, 2017·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sagar DuganiNiranjan Kissoon
May 31, 2017·Seminars in Immunopathology·Benjamin G ChoustermanGeorg F Weber
Jun 20, 2017·Bioscience Trends·Tingmin ZhangYonggui Wu
Aug 16, 2017·Critical Care : the Official Journal of the Critical Care Forum·Ali HassounBruce Friedman
Sep 25, 2017·Nature Reviews. Drug Discovery·Stefan H E KaufmannRalf Bartenschlager
Oct 19, 2017·Chest·Steven Q Simpson
Dec 12, 2017·Nature Reviews. Nephrology·Fabienne Venet, Guillaume Monneret
Sep 12, 2018·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shannon M FernandoAndrew J E Seely
Dec 20, 2018·Microbial Biotechnology·Gerard D Wright
Feb 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xi Chen, Francis Alonzo

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Pharmacology·Wei ZhuangShengyan Xi
Jun 5, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bingqing ShiPeng Gao
Aug 18, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xufei LuoLin Lin
May 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dan ZhangZhi-Jian Lin

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.