Xuebijing Injection () increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns

Chinese Journal of Integrative Medicine
Yue-Long DaiSen Hu

Abstract

To investigate the effects of Xuebijing Injection (, XBJ) on survival rate and pulmonary vasopermeability in a rat model of severe scald injury. Rats were divided into two experiments: experiment 1 was monitored for 12 h post-injury for survival analysis after severe burns; in experiment 2, rats were killed for determination of pulmonary vascular permeability and pro-inflflammatory mediators. In both experiments, rats were subject to third-degree 50% total body surface area (TBSA) burns or sham injury followed by XBJ or normal saline (NS) treatment. In addition, rat pulmonary microvascular endothelium cells (PMECs) were pretreated with either XBJ or phosphate buffer saline (PBS), and then subjected to sham serum or scald serum stimulation for 2 or 6 h, followed by transwell examination for the permeability of PMECs. Meanwhile, pro-inflflammatory mediators in PMECs culture supernatant were also investigated. The average survival time in the scald+XBJ group was 582.1±21.2 min, which was signifificantly longer than that in the scald + NS group (345.8±25.4 min, P<0.01). Plasma levels of tumor necrosis factor-alpha (TNF-α), E-selectin, interleukin-6 (IL-6), vascular permeability and water content of lung tissues were signifificantly...Continue Reading

References

Feb 9, 2002·Burns : Journal of the International Society for Burn Injuries·Hiroyuki SakuraiDaniel L Traber
Sep 26, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Leopoldo C CancioStephen L Hoskins
Jun 10, 2008·Burns : Journal of the International Society for Burn Injuries·Ricardo AlvaradoSteven E Wolf
Nov 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Felicia N WilliamsMarc G Jeschke
Jul 16, 2010·Experimental Dermatology·Lars H EversPeter Mailänder
Nov 1, 2011·Burns : Journal of the International Society for Burn Injuries·Sen HuZhi-Yong Sheng
Aug 27, 2013·Chinese Journal of Integrative Medicine·Yan-bo WangYu-feng Liu
Jan 7, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jessica B ChangPaul S Cederna

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