PMID: 18406227Apr 15, 2008Paper

XX germ cells: the difference between an ovary and a testis

Trends in Endocrinology and Metabolism : TEM
D J Whitworth

Abstract

In mammals, gonadal sex is determined by the action of the testis-determining gene, SRY. In the absence of SRY, the indifferent gonad follows an alternative pathway and develops as an ovary. Both mitotic and meiotic germ cells appear to play an essential role in ensuring ovarian development. Ovaries depleted of germ cells before or after ovarian differentiation has commenced can develop seminiferous cords, suggesting that XX germ cells may inhibit testicular differentiation in the ovary.

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