PMID: 11913502Mar 27, 2002Paper

Xylitol concentrations in the saliva of children after chewing xylitol gum or consuming a xylitol mixture

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
T TapiainenM Uhari

Abstract

Xylitol prevents otitis media when given to children regularly five times per day. To find a more convenient dosing schedule, an enzymatic assay was used to measure xylitol concentrations in the saliva of 65 children after giving them xylitol chewing gum or syrup in doses equal to those used in clinical trials. Although concentrations high enough to have an antimicrobial effect were attained, the xylitol disappeared from the saliva within 15 min. This finding indicates that high peak concentrations are more important for efficacy than the amount of time the xylitol concentration exceeds that needed to produce an antimicrobial effect. A schedule with the same single doses given less frequently could be clinically effective in preventing otitis media.

Citations

Jun 9, 2007·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·T TaipaleE Söderling
Jan 8, 2008·Current Microbiology·Eva M SöderlingTeemu J Taipale
May 1, 2007·The Pediatric Infectious Disease Journal·Outi HautalahtiMatti Uhari
Jul 26, 2014·International Journal of Oral Science·Eva-Maria DeckerChristiane von Ohle
Jan 7, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Paula KurolaAnnika Saukkoriipi
Nov 2, 2011·International Journal of Dental Hygiene·J Burgess, P Lee
Jul 11, 2009·Journal of Medical Microbiology·Paula KurolaAnnika Saukkoriipi
May 9, 2012·Inhalation Toxicology·Matthew D ReedLakshmi Durairaj

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