Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells

International Journal of Oncology
Pei Jou ChuaGyeong Hun Baeg

Abstract

Y-box binding protein-1 (YB-1) facilitates cancer chemoresistance through the upregulation of ATP-binding cassette (ABC) transporters associated with multidrug resistance, which is one of the primary obstacles in cancer treatment. Since aberrant Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling is also implicated in chemoresistance in numerous human malignancies, the interaction between YB-1 and JAK/STAT signaling was explored underlying the chemoresistance of NUGC3 gastric cancer cells. It was demonstrated that YB-1 translocated into the nuclei of NUGC3 cells exposed to doxorubicin hydrochloride, suggesting its important role in chemoresistance. Consistently, knockdown of YB-1 significantly decreased the chemoresistance of cells to doxorubicin hydrochloride and epirubicin hydrochloride, as evidenced by a decrease in cell viability. Notably, JAK inhibitor AG490 treatment further decreased the cell viability caused by YB-1 inhibition and doxorubicin hydrochloride. It was also observed that YB-1 transcriptionally regulated the ABCC3 transporter, whereas STAT3 modulated ABCC2 transporter levels. These findings suggest that YB-1 and STAT3 act together to facilitate chemoresistance via modulating t...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D K DidierB D Schwartz
Jun 24, 2000·Cell Death and Differentiation·A StephanouD S Latchman
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Martin JanzHans-Dieter Royer
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Nov 30, 2002·Journal of Cancer Research and Clinical Oncology·Hideaki YahataHitoo Nakano
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Weida GongSuyun Huang
Nov 4, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wei-Lin TayBoon-Huat Bay
Dec 30, 2008·Advanced Drug Delivery Reviews·Kohji NoguchiYoshikazu Sugimoto
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Dae-Young KimSung-Pyo Hong
Apr 17, 2009·Journal of Gastroenterology and Hepatology·Cameron B Jackson, Andrew S Giraud
Nov 13, 2010·World Journal of Gastroenterology : WJG·Jing-Yu DengHan Liang
Feb 22, 2012·Biochemistry. Biokhimii︠a︡·I A EliseevaD N Lyabin
Feb 22, 2012·Growth Factors·Hiu Kiu, Sandra E Nicholson
Jul 28, 2012·Expert Opinion on Therapeutic Targets·Andrew S GiraudLouise M Judd
Apr 25, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tian Tian GuoBoon Huat Bay
Jul 5, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jingyu DengXishan Hao
Jan 28, 2014·European Journal of Cell Biology·Corinna KosnopfelBirgit Schittek
Oct 25, 2014·Nature Reviews. Cancer·Hua YuRichard Jove
Sep 4, 2015·International Journal of Biological Sciences·Wei ZhangTao Yang
Sep 24, 2015·International Journal of Oncology·Puja KhannaGyeong Hun Baeg
May 25, 2016·World Journal of Gastroenterology : WJG·Moon Kyung JooHoon Jai Chun

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Citations

Jun 18, 2020·Biology·Milad AshrafizadehReza Mohammadinejad

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