Mar 1, 2012

Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls

Gender Medicine
Yingfang TianFrank R Sharp

Abstract

Sex is suggested to be an important determinant of ischemic stroke risk factors, etiology, and outcome. However, the basis for this remains unclear. The Y chromosome is unique in males. Genes expressed in males on the Y chromosome that are associated with stroke may be important genetic contributors to the unique features of males with ischemic stroke, which would be helpful for explaining sex differences observed between men and women. We compared Y chromosome gene expression in males with ischemic stroke and male controls. Blood samples were obtained from 40 male patients ≤3, 5, and 24 hours after ischemic stroke and from 41 male controls (July 2003-April 2007). RNA was isolated from blood and was processed using Affymetrix Human U133 Plus 2.0 expression arrays (Affymetrix Inc., Santa Clara, California). Y chromosome genes differentially expressed between male patients with stroke and male control subjects were identified using an ANCOVA adjusted for age and batch. A P < 0.05 and a fold change >1.2 were considered significant. Seven genes on the Y chromosome were differentially expressed in males with ischemic stroke compared with controls. Five of these genes (VAMP7, CSF2RA, SPRY3, DHRSX, and PLCXD1) are located on pseudoaut...Continue Reading

Mentioned in this Paper

Ischemic Cerebrovascular Accident
Eosinophil
CSF2RA protein, human
Benign Neoplasm of Testis
Y Chromosome
Whole Blood
Systemic Inflammatory Response Syndrome
VAMP7 gene
Angiogenic Process
Schizophrenia

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