Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Shanzana I KhanJaye P F Chin-Dusting

Abstract

The essential role of the Y chromosome in male sex determination has largely overshadowed the possibility that it may exert other biologic roles. Here, we show that Y-chromosome lineage is a strong determinant of perivascular and renal T-cell infiltration in the stroke-prone spontaneously hypertensive rat, which, in turn, may influence vascular function and blood pressure (BP). We also show, for the first time to our knowledge, that augmented perivascular T-cell levels can directly instigate vascular dysfunction, and that the production of reactive oxygen species that stimulate cyclo-oxygenase underlies this. We thus provide strong evidence for the consideration of Y-chromosome lineage in the diagnosis and treatment of male hypertension, and point to the modulation of cardiovascular organ T-cell infiltration as a possible mechanism that underpins Y- chromosome regulation of BP.-Khan, S. I., Andrews, K. L., Jackson, K. L., Memon, B., Jefferis, A.-M., Lee, M. K. S., Diep, H., Wei, Z., Drummond, G. R., Head, G. A., Jennings, G. L., Murphy, A. J., Vinh, A., Sampson, A. K., Chin-Dusting, J. P. F. Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat.

References

Oct 27, 1983·The New England Journal of Medicine·J J CurtisA G Diethelm
Mar 7, 2001·Hypertension·C D NegrínA F Dominiczak
May 23, 2001·Hypertension·J F Reckelhoff
Sep 15, 2005·British Journal of Pharmacology·Pascale GluaisMichel Feletou
Nov 5, 2005·Journal of Hypertension·Pamela StrahornAnna F Dominiczak
Apr 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Michel Félétou, Paul M Vanhoutte
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cory TeuscherElizabeth P Blankenhorn
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Sep 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Elodie GomezMichel Félétou
Jan 27, 2009·Human Genetics·Efe SezginMichael W Smith
Dec 30, 2009·Hypertension·Meena S MadhurDavid G Harrison
Apr 25, 2014·Nature·Daniel W BellottDavid C Page
Jun 18, 2014·Hypertension·Hong JiKathryn Sandberg
Jul 11, 2014·American Journal of Physiology. Renal Physiology·David L Mattson
Jul 30, 2014·Trends in Endocrinology and Metabolism : TEM·Grant R Drummond, Christopher G Sobey
Sep 27, 2014·Hypertension·Daniel W TrottDavid G Harrison
Mar 15, 2015·Circulation Research·William G McMasterDavid G Harrison
Sep 10, 2015·Hypertension·Christopher T ChanGrant R Drummond
Feb 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tomasz P MikolajczykTomasz J Guzik
Aug 31, 2017·European Journal of Human Genetics : EJHG·Akhlaq A MaanMaciej Tomaszewski

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Citations

Apr 18, 2019·Nature Reviews. Immunology·Grant R DrummondChristopher G Sobey
Jun 16, 2019·International Journal of Molecular Sciences·Shanzana I KhanJaye P F Chin-Dusting

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