PMID: 9179696Mar 1, 1997Paper

Y chromosome (Yq11) microdeletions in idiopathic azoospermia

International Journal of Urology : Official Journal of the Japanese Urological Association
T ShirakawaS Kamidono

Abstract

Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11. We studied Y chromosome microdeletions in the Yq11.23 region in idiopathic azoospermia. We studied 25 azoospermic male patients with a cytogenetically normal 46XY karyotype; 13 exhibited Sertoli-cell-only syndrome and 12 exhibited maturation arrest. Microdeletions in the Yq11 region were examined using the PCR technique with 4 pairs of primers from DNA loci in Yq11.23. Microdeletions in Yq11.23 were detected in 4 of the 25 azoospermic men. The most common deletion was of the Y6HP52pr sequence, which was detected in 3 of 13 men with Sertoli-cell-only syndrome but in only 1 of 12 with maturation arrest. Detection of microdeletions within the Yq11 sequence is an important clue to the genetic factor(s) underlying azoospermia.

References

Dec 1, 1989·American Journal of Obstetrics and Gynecology·M D JohnsonP G McDonough
Jan 1, 1985·American Journal of Medical Genetics·N FitchA Kahn
Jan 1, 1994·Human Molecular Genetics·A C Chandley, H J Cooke
Oct 1, 1993·The Journal of Urology·S NagafuchiY Nakagome

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Citations

Dec 20, 2002·Genetic Testing·Patricia De C PieriCarlos A Moreira-Filho
Apr 30, 2014·Annual Review of Genomics and Human Genetics·Corey T WatsonHeather C Mefford
Feb 9, 1999·Prenatal Diagnosis·E D KimD J Lamb

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